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rs2834167

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2.1 2.67x increased risk for systemic sclerosis
(A;G) 0 normal
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome21
Position33268483
GeneIL10RB
is asnp
is mentioned by
dbSNPrs2834167
ebirs2834167
HLIrs2834167
Exacrs2834167
Varsomers2834167
Maprs2834167
PheGenIrs2834167
hapmaprs2834167
1000 genomesrs2834167
hgdprs2834167
ensemblrs2834167
gopubmedrs2834167
geneviewrs2834167
scholarrs2834167
googlers2834167
pharmgkbrs2834167
gwascentralrs2834167
openSNPrs2834167
23andMers2834167
23andMe allrs2834167
SNP Nexus

SNPshotrs2834167
SNPdbers2834167
MSV3drs2834167
GWAS Ctlgrs2834167
GMAF0.3448
Max Magnitude2.1
? (A;A) (A;G) (G;G) 28
rs2834167 is a SNP in the interleukin-10 receptor 2 IL10RB gene.

In a study of Japanese patients, rs2834167(A;A) individuals were at increased risk for diffuse cutaneous systemic sclerosis (odds ratio 2.67, p = 0.0018).[PMID 18588853]

OMIM123889
Desc
Variant0001
Relatedalso


ClinVar
Risk rs2834167(G;G)
Alt rs2834167(G;G)
Reference rs2834167(A;A)
Significance Other
Disease Hepatitis b virus
Variation info
Gene IL10RB
CLNDBN Hepatitis b virus, susceptibility to
Reversed 0
HGVS NC_000021.8:g.34640788A>G
CLNSRC OMIM Allelic Variant
CLNACC RCV000018431.2,



[PMID 19604093OA-icon.png] Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.


[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.


[PMID 21532858OA-icon.png] Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population.


GET Evidence
IL10RB-K47E
aa_change Lys47Glu
aa_change_short K47E
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency
summary



[PMID 23096091] Association between IL10, IL10RA, and IL10RB SNPs and ischemic stroke with hypertension in Korean population.


[PMID 23749100] IL-10RB rs2834167 (A/G) polymorphism is associated with the susceptibility to systemic lupus erythematosus: evidence from a study in Chinese Han population.


[PMID 25032264] Role of IFN-ks, IFN-ks related genes and the DEPDC5 gene in Hepatitis B virus-related liver disease