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rs2834167(A;A)

From SNPedia

2.67x increased risk for systemic sclerosis
Is agenotype
ofrs2834167
GeneIL10RB
Chromosome21
Position33,268,483
mentionedby
Magnitude2.1
ReputeBad
Geno Mag Summary
(A;A) 2.1 2.67x increased risk for systemic sclerosis
(A;G) 0 normal
(G;G) 0 normal

[PMID 24819332] IL-10RB rs2834167 (A/G) polymorphism is associated with the susceptibility to systemic lupus erythematosus: evidence from a study in Chinese Han population. We found that the frequency of A allele for rs2834167 in patients (44.53 %) was significantly higher than in controls (40.16 %) (χ (2) = 5.24, P = 0.022). Allele A was associated with a 1.196-fold (95 % confidence interval (CI), 1.026-1.394) greater risk for the occurrence of SLE compared with the G allele. And both genotypes AG and AA were associated with the susceptibility to SLE as compared with the GG genotype (AG versus GG, odds ratio (OR) = 1.332; 95 %CI, 1.047-1.696; AA versus GG, OR = 1.373; 95 %CI, 1.004-1.878).