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rs28362491

From SNPedia

Orientationplus
Stabilizedplus
Make rs28362491(-;-)
Make rs28362491(-;ATTG)
Make rs28362491(ATTG;ATTG)
ReferenceGRCh38 38.1/141
Chromosome4
Position102500998
GeneNFKB1
is asnp
is mentioned by
dbSNPrs28362491
ebirs28362491
HLIrs28362491
Exacrs28362491
Varsomers28362491
Maprs28362491
PheGenIrs28362491
hapmaprs28362491
1000 genomesrs28362491
hgdprs28362491
ensemblrs28362491
gopubmedrs28362491
geneviewrs28362491
scholarrs28362491
googlers28362491
pharmgkbrs28362491
gwascentralrs28362491
openSNPrs28362491
23andMers28362491
23andMe allrs28362491
SNP Nexus

SNPshotrs28362491
SNPdbers28362491
MSV3drs28362491
GWAS Ctlgrs28362491
Merged fromRs28720239
GMAF0.4472
Max Magnitude

rs28362491, also known as the -94 ATTG insertion/deletion polymorphism, is a SNP in the promoter (upstream) region of the NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 gene.

Several studies have seen differences between men and women for this SNP (such as [PMID 24818816OA-icon.png]), and others have seen differences between Asians and Caucasians (such as [PMID 24827594]). Any genotype summaries for this SNP should state which gender and ethnicity any summary is applicable to.


[PMID 19892748] Relationship between NFKB1 -94 insertion/deletion ATTG polymorphism and susceptibility of cervical squamous cell carcinoma risk

[PMID 20836841OA-icon.png] Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes

[PMID 22013908] NFKB1 -94 Insertion/Deletion ATTG Polymorphism Contributes to Risk of Systemic Lupus Erythematosus [PMID 19480714OA-icon.png] Functional polymorphism of the NFKB1 gene promoter is related to the risk of dilated cardiomyopathy.


[PMID 19734419OA-icon.png] A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support.


[PMID 21245992OA-icon.png] Polymorphisms in NF-kappaB, PXR, LXR, PPARgamma and risk of inflammatory bowel disease.


[PMID 22614238] NFKB1 polymorphism is associated with age-related gene methylation in Helicobacter pylori-infected subjects.

[PMID 23806437] The functional -94 insertion/deletion ATTG polymorphism in the promoter region of NFKB1 gene increases the risk of sporadic colorectal cancer

[PMID 24578542OA-icon.png] Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case-control study in Shanghai, China [PMID 22742859] NFKB1-94ATTG ins/del polymorphism (rs28362491) is associated with cardiovascular disease in patients with rheumatoid arthritis.


[PMID 22902396] The nuclear factor-kB functional promoter polymorphism is associated with endometriosis and infertility.


[PMID 23299027] The NFKB1 -94 ATTG insertion/deletion polymorphism (rs28362491) contributes to the susceptibility of congenital heart disease in a Chinese population.


[PMID 23357300] Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease (CAD) patients.


[PMID 23543433] Gene polymorphisms and thyroid function in patients with heart failure.

[PMID 24895544OA-icon.png] Association between NFKB1 -94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis

[PMID 24971461OA-icon.png] Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort

[PMID 25223483] Effect of functional nuclear factor kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma

[PMID 25304949] Role of Genetic Polymorphisms in NFKB-Mediated Inflammatory Pathways in Response to Primary Chemoradiation Therapy for Rectal Cancer

[PMID 25692306] A Functional Insertion/Deletion Polymorphism in the Promoter Region of the NFKB1 Gene Increases the Risk of Papillary Thyroid Carcinoma

[PMID 26053525] Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease

[PMID 26075620OA-icon.png] Genetic Variation in NFKB1 and NFKBIA and Susceptibility to Coronary Artery Disease in a Chinese Uygur Population

[PMID 26563375] Association and interaction of NFKB1 rs28362491 insertion/deletion ATTG polymorphism and PPP1R13L and CD3EAP related to lung cancer risk in a Chinese population [PMID 26885097] Association between genetic polymorphism in NFKB1 and NFKBIA and coronary artery disease in a Chinese Han population. [PMID 26919710] Variations in genes involved in regulation of the nuclear factor - κB pathway and the risk of acute myeloid leukaemia.


[PMID 27488439] Co-stimulatory CD28 and transcription factor NFKB1 gene variants affect idiopathic recurrent miscarriages.

[PMID 27525877] Association of NF-κB1 gene polymorphisms with coronary artery disease in a Han Chinese population.