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rs28371686

From SNPedia

Warfarin (Coumadin®)
Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal
(C;G) carrier of one CYP2C9*5 allele
(G;G) 2.5 CYP2C9*5 homozygote
ReferenceGRCh38 38.1/142
Chromosome10
Position94981301
GeneCYP2C9
is asnp
is mentioned by
dbSNPrs28371686
ebirs28371686
HLIrs28371686
Exacrs28371686
Varsomers28371686
Maprs28371686
PheGenIrs28371686
hapmaprs28371686
1000 genomesrs28371686
hgdprs28371686
ensemblrs28371686
gopubmedrs28371686
geneviewrs28371686
scholarrs28371686
googlers28371686
pharmgkbrs28371686
gwascentralrs28371686
openSNPrs28371686
23andMers28371686
23andMe allrs28371686
SNP Nexus

SNPshotrs28371686
SNPdbers28371686
MSV3drs28371686
GWAS Ctlgrs28371686
GMAF0.005051
Max Magnitude2.5
CPMC Logo.png

This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
Additional information is available here

rs28371686, also known as 1080C>G, 42619C>G or D360E, is a SNP in the CYP2C9 gene.

The rs28371686(G) allele defines the CYP2C9*5 variant, which appears to have decreased activity.


[PMID 20214591] Pharmacogenomics in aspirin intolerance



[PMID 18466099OA-icon.png] Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans.


[PMID 18752379OA-icon.png] Warfarin pharmacogenetics.


[PMID 23133420OA-icon.png] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.


ClinVar
Risk rs28371686(A,G;A,G)
Alt rs28371686(A,G;A,G)
Reference rs28371686(C;C)
Significance Drug-response
Disease warfarin response - Dosage
Variation info
Gene CYP2C9
CLNDBN warfarin response - Dosage
Reversed 0
HGVS NC_000010.10:g.96741058C>G
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211141.1,