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rs28371706

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 normal
(C;T) Carrier of one CYP2D6 variant, possibly decreased on non-functioning.
(T;T) Homozygous for CYP2D6 variants, possibly decreased or non-functioning.
ReferenceGRCh38 38.1/142
Chromosome22
Position42525772
GeneCYP2D6
is asnp
is mentioned by
dbSNPrs28371706
ebirs28371706
HLIrs28371706
Exacrs28371706
Varsomers28371706
Maprs28371706
PheGenIrs28371706
hapmaprs28371706
1000 genomesrs28371706
hgdprs28371706
ensemblrs28371706
gopubmedrs28371706
geneviewrs28371706
scholarrs28371706
googlers28371706
pharmgkbrs28371706
gwascentralrs28371706
openSNPrs28371706
23andMers28371706
23andMe allrs28371706
SNP Nexus

SNPshotrs28371706
SNPdbers28371706
MSV3drs28371706
GWAS Ctlgrs28371706
GMAF0.04867
Max Magnitude0
rs28371706, also known as 1023C>T or T107I, is a SNP in the CYP2D6 gene.

The rs28371706(T) allele is found in several CYP2D6 variants:

  • CYP2D6*17 decreased activity variant
  • CYP2D6*40 non-functioning variant
  • CYP2D6*58 variant
  • CYP2D6*64 variant



[PMID 18547414OA-icon.png] Genotyping panel for assessing response to cancer chemotherapy.


GET Evidence
CYP2D6-T107I
aa_change Thr107Ile
aa_change_short T107I
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0606287
summary



[PMID 23133420OA-icon.png] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.