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rs28399433

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) 2 Reduced CYP2A6 metabolism; impaired nicotine metabolism?
(G;T) 1 Reduced CYP2A6 metabolism; impaired nicotine metabolism?
(T;T) 0
ReferenceGRCh38 38.1/141
Chromosome19
Position40850474
GeneCYP2A6
is asnp
is mentioned by
dbSNPrs28399433
ebirs28399433
HLIrs28399433
Exacrs28399433
Varsomers28399433
Maprs28399433
PheGenIrs28399433
hapmaprs28399433
1000 genomesrs28399433
hgdprs28399433
ensemblrs28399433
gopubmedrs28399433
geneviewrs28399433
scholarrs28399433
googlers28399433
pharmgkbrs28399433
gwascentralrs28399433
openSNPrs28399433
23andMers28399433
23andMe allrs28399433
SNP Nexus

SNPshotrs28399433
SNPdbers28399433
MSV3drs28399433
GWAS Ctlgrs28399433
GMAF0.1336
Max Magnitude2
rs28399433, also known as -47A>C, is a SNP in the CYP2A6 gene.


[PMID 19339270] Genetic Associations of 115 Polymorphisms with Cancers of the Upper Aerodigestive Tract across 10 European Countries: The ARCAGE Project.



[PMID 22046326OA-icon.png] 'Smoking Genes': A Genetic Association Study

[PMID 19371316OA-icon.png] CYP2B6 (c.516G-->T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients.

[PMID 19659438OA-icon.png] CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti.


GET Evidence
rs28399433
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0684396
summary



[PMID 24080498] Pharmacogenetic associations with plasma efavirenz concentrations and clinical correlates in a retrospective cohort of Ghanaian HIV-infected patients