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rs2856758

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in complete genomics
Make rs2856758(A;G)
Make rs2856758(G;G)
ReferenceGRCh38 38.1/141
Chromosome3
Position46370170
GeneCCR5, LOC102724297
is asnp
is mentioned by
dbSNPrs2856758
ebirs2856758
HLIrs2856758
Exacrs2856758
Varsomers2856758
Maprs2856758
PheGenIrs2856758
hapmaprs2856758
1000 genomesrs2856758
hgdprs2856758
ensemblrs2856758
gopubmedrs2856758
geneviewrs2856758
scholarrs2856758
googlers2856758
pharmgkbrs2856758
gwascentralrs2856758
openSNPrs2856758
23andMers2856758
23andMe allrs2856758
SNP Nexus

SNPshotrs2856758
SNPdbers2856758
MSV3drs2856758
GWAS Ctlgrs2856758
GMAF0.07759
Max Magnitude0
Rs2856758 is a SNP in the CCR5 gene (CC-chemokine receptor type 5). Variants in CCR5 are associated with resistance to HIV infection. [1]

Another mutation in this gene, rs333 (also known as the CCR5-delta32 deletion), is associated with resistance to HIV. This mutation may have spread in the European population in response to selection pressure from plague (Black Death) or smallpox. [2]

[PMID 16055130] Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women.

[PMID 20206716OA-icon.png] Genetic variation within the gene encoding the HIV-1 CCR5 coreceptor in two South African populations.

[PMID 20552027OA-icon.png] Host and viral genetic correlates of clinical definitions of HIV-1 disease progression.