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rs2881766

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 1 Normal risk for pregnancy-induced hypertension
(G;T) 1.5 Slightly increased risk for pregnancy-induced hypertension
(T;T) 1.5 Slightly increased risk for pregnancy-induced hypertension
ReferenceGRCh38 38.1/141
Chromosome6
Position151797984
GeneESR1
is asnp
is mentioned by
dbSNPrs2881766
ebirs2881766
HLIrs2881766
Exacrs2881766
Varsomers2881766
Maprs2881766
PheGenIrs2881766
hapmaprs2881766
1000 genomesrs2881766
hgdprs2881766
ensemblrs2881766
gopubmedrs2881766
geneviewrs2881766
scholarrs2881766
googlers2881766
pharmgkbrs2881766
gwascentralrs2881766
openSNPrs2881766
23andMers2881766
23andMe allrs2881766
SNP Nexus

SNPshotrs2881766
SNPdbers2881766
MSV3drs2881766
GWAS Ctlgrs2881766
GMAF0.4118
Max Magnitude1.5
? (G;G) (G;T) (T;T) 28
rs2881766 is a SNP in the promoter region of the estrogen receptor alpha ESR1 gene.

Carriers of rs2881766(T) alleles are at somewhat (slightly) higher risk for pregnancy-induced hypertension.[PMID 18360040]


[PMID 18408366OA-icon.png] Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome.


[PMID 18636124OA-icon.png] Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.


[PMID 25323936] Genetic polymorphism of ESR1 rs2881766 increases breast cancer risk in Korean women


[PMID 26850117] The association between a novel polymorphism (rs1062577) in ESR1 and breast cancer susceptibility in the Han Chinese women.