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rs2943634

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2.5 lower risk of ischemic stroke
(C;C) 2.5 higher risk of ischemic stroke
Make rs2943634(A;C)
ReferenceGRCh38 38.1/141
Chromosome2
Position226203364
is asnp
is mentioned by
dbSNPrs2943634
ebirs2943634
HLIrs2943634
Exacrs2943634
Varsomers2943634
Maprs2943634
PheGenIrs2943634
hapmaprs2943634
1000 genomesrs2943634
hgdprs2943634
ensemblrs2943634
gopubmedrs2943634
geneviewrs2943634
scholarrs2943634
googlers2943634
pharmgkbrs2943634
gwascentralrs2943634
openSNPrs2943634
23andMers2943634
23andMe allrs2943634
SNP Nexus

SNPshotrs2943634
SNPdbers2943634
MSV3drs2943634
GWAS Ctlgrs2943634
GMAF0.3214
Max Magnitude2.5
? (A;A) (A;C) (C;C) 28
rs2943634 is a SNP found to be reproducibly associated with heart disease [PMID 17634449OA-icon.png]

[PMID 18979498OA-icon.png] rs2943634 associated with high density lipoprotein (HDL) cholesterol

GWAS
SNP rs2943634
PubMedID [PMID 17634449OA-icon.png]
Condition Coronary disease
Gene pseudogene
Risk Allele C
pValue 2.00E-007
OR 1.21
95% CI 1.13-1.30


[PMID 19164808OA-icon.png] Large scale association analysis of novel genetic loci for coronary artery disease


[PMID 18675980OA-icon.png] Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes



[PMID 19373437] Association of three polymorphisms selected from a genome-wide association study with coronary heart disease in the Tunisian population


[PMID 21463265OA-icon.png] Association of SNP rs17465637 on Chromosome 1q41 and rs599839 on 1p13.3 with Myocardial Infarction in an American Caucasian Population


[PMID 22207032] Significant associations of the rs2943634 (2q36.3) genetic polymorphism with adiponectin, high density lipoprotein cholesterol and ischemic stroke

[PMID 18780302OA-icon.png] Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.

[PMID 19135198] Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease.

[PMID 19198609OA-icon.png] Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

[PMID 19750184OA-icon.png] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

[PMID 19956433OA-icon.png] Genetics of coronary artery disease: focus on genome-wide association studies.

[PMID 20017983OA-icon.png] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.

[PMID 21804106OA-icon.png] Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.

[PMID 22042884OA-icon.png] Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.

GWAS snp
PMID [PMID 22581228OA-icon.png]
Trait
Title A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Risk Allele
P-val 2E-14
Odds Ratio None None


GET Evidence
rs2943634
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.596774
summary



[PMID 23101478OA-icon.png] Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study


[PMID 23659870OA-icon.png] Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study


[PMID 22797928] Evidence of selection at insulin receptor substrate-1 gene loci.