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rs2943641

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) increased risk for type 2 diabetes
(C;T) increased risk for type 2 diabetes
Make rs2943641(T;T)
ReferenceGRCh38 38.1/141
Chromosome2
Position226229029
is asnp
is mentioned by
dbSNPrs2943641
ebirs2943641
HLIrs2943641
Exacrs2943641
Varsomers2943641
Maprs2943641
PheGenIrs2943641
hapmaprs2943641
1000 genomesrs2943641
hgdprs2943641
ensemblrs2943641
gopubmedrs2943641
geneviewrs2943641
scholarrs2943641
googlers2943641
pharmgkbrs2943641
gwascentralrs2943641
openSNPrs2943641
23andMers2943641
23andMe allrs2943641
SNP Nexus

SNPshotrs2943641
SNPdbers2943641
MSV3drs2943641
GWAS Ctlgrs2943641
GMAF0.2686
Max Magnitude
? (C;C) (C;T) (T;T) 28

[PMID 19734900] Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

10.1371/journal.pone.0026911 identified a significant association of rs2943641 near IRS1 locus, with type 2 diabetes in the Japanese population.

OMIM147545
Desc
Variant
Relatedalso


[PMID 22576021] Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population


[PMID 21917432OA-icon.png] IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.


[PMID 22253814OA-icon.png] A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme

[PMID 20043853OA-icon.png] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.

[PMID 21353221OA-icon.png] The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects.

[PMID 21747052OA-icon.png] Insulin receptor substrate 1 gene variation modifies insulin resistance response to weight-loss diets in a 2-year randomized trial: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.


GET Evidence
rs2943641
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.710938
summary



[PMID 23418314] The IRS1 rs2943641 Variant and Risk of Future Cancer Among Morbidly Obese Individuals


[PMID 23036851] Treatment factors rather than genetic variation determine metabolic syndrome in childhood cancer survivors


[PMID 23659870OA-icon.png] Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study


[PMID 24255076OA-icon.png] Circulating 25-Hydroxyvitamin D, IRS1 Variant rs2943641, and Insulin Resistance: Replication of a Gene-Nutrient Interaction in 4 Populations of Different Ancestries


[PMID 24493031] Association of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi population


[PMID 26582067] Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene and type 2 diabetes susceptibility: a meta-analysis