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rs2965667

From SNPedia

Stabilizedplus
Geno Mag Summary
(A;A) 2 aspirin use may increase colorectal cancer risk a bit
(A;T) 2 aspirin use may increase colorectal cancer risk a bit
(T;T) 2 common/normal; aspirin use reduces colorectal cancer risk a bit
is asnp
is mentioned by
dbSNPrs2965667
ebirs2965667
HLIrs2965667
Exacrs2965667
Varsomers2965667
Maprs2965667
PheGenIrs2965667
hapmaprs2965667
1000 genomesrs2965667
hgdprs2965667
ensemblrs2965667
gopubmedrs2965667
geneviewrs2965667
scholarrs2965667
googlers2965667
pharmgkbrs2965667
gwascentralrs2965667
openSNPrs2965667
23andMers2965667
23andMe allrs2965667
SNP Nexus

SNPshotrs2965667
SNPdbers2965667
MSV3drs2965667
GWAS Ctlgrs2965667
Max Magnitude2
? (A;A) (A;T) (T;T) 28
rs2965667 is a SNP on chromosome 12p12.3 near the MGST1 gene.

In a long-term study of ~17,000 individuals and aspirin or NSAID use, the few (4%) with either an (A;T) or (A;A) genotype were almost twice as likely to be diagnosed with colorectal cancer compared with (T;T) individuals among those taking anti-inflammatory drugs (prevalence, 28% vs 38%; (T;T) odds ratio 0.66 when taking aspirin/NSAID, CI: 0.61-0.70, p = 7.7 × 10e−33); prevalence, 35% vs 29%; (A;T) and (A;A) odds ratio 1.89 when taking aspirin/NSAID, CI: 1.27-2.81, p = .002). 10.1001/jama.2015.1815

If this data is robust and all other factors are equal, this indicates that most people will lower their colorectal cancer risk by taking aspirin or NSAIDs, since most people have rs2965667(T;T) genotypes. However, the few people who are rs2965667(A;T) or are rs2965667(A;A) should not take aspirin or NSAIDs since doing so may actually raise their colorectal risk.

This same study reached somewhat similar conclusions about two other SNPs, rs10505806 and rs16973225.10.1001/jama.2015.1815

[PMID 25781442] Association of Aspirin and NSAID Use With Risk of Colorectal Cancer According to Genetic Variants