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rs2987983

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 2 1.2x increased risk of prostate cancer
(C;T) 2 1.2x increased risk of prostate cancer
(T;T) 0 normal risk
ReferenceGRCh38 38.1/141
Chromosome14
Position64296935
GeneESR2
is asnp
is mentioned by
dbSNPrs2987983
ebirs2987983
HLIrs2987983
Exacrs2987983
Varsomers2987983
Maprs2987983
PheGenIrs2987983
hapmaprs2987983
1000 genomesrs2987983
hgdprs2987983
ensemblrs2987983
gopubmedrs2987983
geneviewrs2987983
scholarrs2987983
googlers2987983
pharmgkbrs2987983
gwascentralrs2987983
openSNPrs2987983
23andMers2987983
23andMe allrs2987983
SNP Nexus

SNPshotrs2987983
SNPdbers2987983
MSV3drs2987983
GWAS Ctlgrs2987983
GMAF0.3907
Max Magnitude2
? (C;C) (C;T) (T;T) 28

[PMID 16921512] In one large Swedish study, men with one or two rs2987983(C) alleles were reported to be at somewhat increased (odds ratio 1.22) risk for Prostate cancer compared to men homozygous for the wild type rs2987983(T) allele, however the risk can be reduced by adding phytoestrogens to the diet.


[PMID 19429453] Polymorphisms in the promoter region of ESR2 gene and breast cancer susceptibility

OMIM601663
DescESTROGEN RECEPTOR 2; ESR2
Variant
Relatedalso



[PMID 20390341] A systematic review of the relationship between polymorphic sites in the estrogen receptor-beta (ESR2) gene and breast cancer risk


[PMID 16551880] Estrogen receptor beta polymorphism is associated with prostate cancer risk.


[PMID 17935138OA-icon.png] Haplotypes of the estrogen receptor beta gene and breast cancer risk.


[PMID 18304720] Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse.


[PMID 18704709OA-icon.png] Genetic polymorphisms in the estrogen receptor beta (ESR2) gene and the risk of epithelial ovarian carcinoma.


[PMID 19337586OA-icon.png] Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?


[PMID 19639498] Estrogen receptor beta gene polymorphisms and susceptibility to uterine fibroids.


[PMID 19654868OA-icon.png] Genetic polymorphisms of estrogen receptors alpha and beta and the risk of developing prostate cancer.


[PMID 20215396] Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation?


GET Evidence
rs2987983
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.460938
summary



[PMID 23149914OA-icon.png] Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women


[PMID 23711151OA-icon.png] Significance of rs1271572 in the estrogen receptor beta gene promoter and its correlation with breast cancer in a southwestern Chinese population


[PMID 24430361] Genetic polymorphisms of ESR1, ESR2, CYP17A1, and CYP19A1 and the risk of breast cancer: a case control study from North India


[PMID 24881814] Polymorphisms in the promoter region of ESR2 gene and susceptibility to ovarian cancer