|(C;C)||2||1.2x increased risk of prostate cancer|
|(C;T)||2||1.2x increased risk of prostate cancer|
[PMID 16921512] In one large Swedish study, men with one or two rs2987983(C) alleles were reported to be at somewhat increased (odds ratio 1.22) risk for Prostate cancer compared to men homozygous for the wild type rs2987983(T) allele, however the risk can be reduced by adding phytoestrogens to the diet.
[PMID 19429453] Polymorphisms in the promoter region of ESR2 gene and breast cancer susceptibility
[PMID 20390341] A systematic review of the relationship between polymorphic sites in the estrogen receptor-beta (ESR2) gene and breast cancer risk
[PMID 16551880] Estrogen receptor beta polymorphism is associated with prostate cancer risk.
[PMID 17935138] Haplotypes of the estrogen receptor beta gene and breast cancer risk.
[PMID 18304720] Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse.
[PMID 18704709] Genetic polymorphisms in the estrogen receptor beta (ESR2) gene and the risk of epithelial ovarian carcinoma.
[PMID 19337586] Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?
[PMID 19639498] Estrogen receptor beta gene polymorphisms and susceptibility to uterine fibroids.
[PMID 19654868] Genetic polymorphisms of estrogen receptors alpha and beta and the risk of developing prostate cancer.
[PMID 20215396] Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation?
|qualified_impact||Insufficiently evaluated pharmacogenetic|
[PMID 23149914] Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women
[PMID 23711151] Significance of rs1271572 in the estrogen receptor beta gene promoter and its correlation with breast cancer in a southwestern Chinese population
[PMID 24430361] Genetic polymorphisms of ESR1, ESR2, CYP17A1, and CYP19A1 and the risk of breast cancer: a case control study from North India
[PMID 24881814] Polymorphisms in the promoter region of ESR2 gene and susceptibility to ovarian cancer