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rs3018362

From SNPedia

Orientationplus
Stabilizedplus
Make rs3018362(A;A)
Make rs3018362(A;G)
Make rs3018362(G;G)
ReferenceGRCh38 38.1/141
Chromosome18
Position62414860
GeneRPL17P44
is asnp
is mentioned by
dbSNPrs3018362
ebirs3018362
HLIrs3018362
Exacrs3018362
Varsomers3018362
Maprs3018362
PheGenIrs3018362
hapmaprs3018362
1000 genomesrs3018362
hgdprs3018362
ensemblrs3018362
gopubmedrs3018362
geneviewrs3018362
scholarrs3018362
googlers3018362
pharmgkbrs3018362
gwascentralrs3018362
openSNPrs3018362
23andMers3018362
23andMe allrs3018362
SNP Nexus

SNPshotrs3018362
SNPdbers3018362
MSV3drs3018362
GWAS Ctlgrs3018362
GMAF0.416
Max Magnitude
? (A;A) (A;G) (G;G) 28

rs3018362 increases susceptibility to Osteoporotic fractures for carriers of the A allele [PMID 18445777]

related to Paget’s disease of bone 23andMe blog.

GWAS snp
PMID [PMID 20436471OA-icon.png]
Trait Paget's disease
Title Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone
Risk Allele A
P-val 5E-13
Odds Ratio 1.52 [1.36-1.70]
OMIM602080
Desc
Variant
Relatedalso
GWAS snp
PMID [PMID 21623375]
Trait
Title Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.
Risk Allele A
P-val 8E-21
Odds Ratio 1.4500 [1.34-1.56]


[PMID 20072603OA-icon.png] Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.


[PMID 20534768OA-icon.png] OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.


[PMID 20554715] Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.


GET Evidence
rs3018362
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.703125
summary



[PMID 23531404] Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women.


[PMID 24921058OA-icon.png] Receptor activator of nuclear factor kappa-B gene polymorphisms in Iranian periodontitis and peri-implantitis patients


[PMID 25464125] RANK/RANKL/OPG pathway: genetic associations with stress fracture period prevalence in elite athletes