|(C;C)||1.2||Normal low risk (0.1%) for ankylosing spondylitis.|
|(C;T)||1.5||1.4x higher risk for Ankylosing Spondylitis.|
|(T;T)||2||2x higher risk for Ankylosing Spondylitis.|
[PMID 19404951] Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis
[PMID 19917163] Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population
[PMID 20032103] Association of ARTS1 Gene Polymorphisms with Ankylosing Spondylitis in the Hungarian Population: The rs27044 Variant Is Associated with HLA-B*2705 Subtype in Hungarian Patients with Ankylosing Spondylitis
|Title||Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.|
|Odds Ratio||None None|
[PMID 22034108] Radiographic severity in ankylosing spondylitis is associated with polymorphism in large multifunctional peptidase 2 (LMP2) in the SPARCC cohort
[PMID 22253828] A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis.
[PMID 22632381] ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis
[PMID 21229357] The association between seven ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis involving 8,530 cases and 12,449 controls
[PMID 18846218] Evolutionary signatures of common human cis-regulatory haplotypes.
[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
[PMID 19433412] Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.
[PMID 19692350] Investigating the genetic association between ERAP1 and ankylosing spondylitis.
[PMID 19849816] Genetics of rheumatic disease.
[PMID 20595269] Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms.
[PMID 20843824] Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection.
[PMID 21281511] Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis.
[PMID 21865284] ERAP1 polymorphisms and haplotypes are associated with ankylosing spondylitis susceptibility and functional severity in a Spanish population.
[PMID 21877190] Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.
[PMID 22355039] Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis.
[PMID 22896742] Investigating the genetic association between ERAP1 and spondyloarthritis
|qualified_impact||Insufficiently evaluated not reviewed|
[PMID 23093722] Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritis
[PMID 23800305] Functional variants of ERAP1 gene are associated with HLA-B27 positive spondyloarthritis
[PMID 22931917] Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-C*06.
[PMID 25740711] ERAP1 gene expression is influenced by non-synonymous polymorphisms associated with predisposition to spondyloarthritis
[PMID 25994336] Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1