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rs3024505

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0
Make rs3024505(C;T)
Make rs3024505(T;T)
ReferenceGRCh38 38.1/141
Chromosome1
Position206766559
GeneIL10
is asnp
is mentioned by
dbSNPrs3024505
ebirs3024505
HLIrs3024505
Exacrs3024505
Varsomers3024505
Maprs3024505
PheGenIrs3024505
hapmaprs3024505
1000 genomesrs3024505
hgdprs3024505
ensemblrs3024505
gopubmedrs3024505
geneviewrs3024505
scholarrs3024505
googlers3024505
pharmgkbrs3024505
gwascentralrs3024505
openSNPrs3024505
23andMers3024505
23andMe allrs3024505
SNP Nexus

SNPshotrs3024505
SNPdbers3024505
MSV3drs3024505
GWAS Ctlgrs3024505
GMAF0.09091
Max Magnitude0
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 18836448]
Trait Ulcerative colitis
Title Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Risk Allele T
P-val 9.9999999999999998E-13
Odds Ratio 1.46 [1.31-1.62]
GWAS snp
PMID [PMID 19430480OA-icon.png]
Trait Type 1 diabetes
Title Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Risk Allele
P-val 2E-9
Odds Ratio 1.19 [1.10-1.30]
OMIM612381
DescINFLAMMATORY BOWEL DISEASE 23; IBD23
Variant
Relatedalso


GWAS snp
PMID [PMID 20228799OA-icon.png]
Trait Ulcerative colitis
Title Genome-wide association identifies multiple ulcerative colitis susceptibility loci
Risk Allele T
P-val 1E-8
Odds Ratio 1.23 [NR]

[PMID 20509889OA-icon.png] The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study



GWAS snp
PMID [PMID 21102463OA-icon.png]
Trait
Title Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Risk Allele T
P-val 2E-14
Odds Ratio 1.1200 [1.07-1.17]
OMIM222100
Desc
Variant
Relatedalso
GWAS snp
PMID [PMID 21297633OA-icon.png]
Trait
Title Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Risk Allele A
P-val 6E-17
Odds Ratio 1.2500 [1.19-1.32]
GWAS snp
PMID [PMID 21829393OA-icon.png]
Trait
Title Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
Risk Allele G
P-val 5E-10
Odds Ratio 1.2000 [NR]


[PMID 22594912OA-icon.png] Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study


[PMID 19468064OA-icon.png] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.


[PMID 19505919OA-icon.png] Toll-like receptor signaling pathway variants and prostate cancer mortality.


[PMID 19698145OA-icon.png] Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.


[PMID 19776214OA-icon.png] SimCT: a generic tool to visualize ontology-based relationships for biological objects.


[PMID 19838195OA-icon.png] A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.


[PMID 20444268OA-icon.png] Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.


[PMID 21245992OA-icon.png] Polymorphisms in NF-kappaB, PXR, LXR, PPARgamma and risk of inflammatory bowel disease.


[PMID 21304977OA-icon.png] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.


[PMID 21354456] The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population.


[PMID 21379322OA-icon.png] Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes.


[PMID 21408207OA-icon.png] Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.


GET Evidence
rs3024505
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.109375
summary



GWAS snp
PMID [PMID 23128233OA-icon.png]
Trait Inflammatory bowel disease
Title Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Risk Allele A
P-val 7E-42
Odds Ratio 1.21 [1.163-1.254]


[PMID 24130510OA-icon.png] Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression


[PMID 24194923OA-icon.png] Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study


[PMID 23348120] Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohn's disease.


[PMID 24971461OA-icon.png] Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort


[PMID 26109419] Polymorphisms in ATP-binding cassette transporter genes and interaction with diet and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study


[PMID 27558476] The Polymorphism rs3024505 (C/T) Downstream of the IL10 Gene Is Associated with Crohn's Disease in Serbian Patients with Inflammatory Bowel Disease.