|(-;-)||5A/5A; higher MI risk?|
|(T;T)||6A/6A; higher CAD risk|
There have been numerous studies in the last 10+ years linking either the 5A or 6A allele to risk for myocardial infarction or coronary artery disease. A relatively recent meta-analysis combining seven previously published studies concluded that the 5A allele is indeed a plaque-disrupting risk factor (odds ratio 1.26, CI: 1.1 - 1.4, p<0.001), while the 6A allele is associated with greater progression of coronary atherosclerosis and the 6A/6A genotype is associated with a worse progression of coronary artery disease after angioplasty. However, all these studies show a lot of heterogeneity, and gender, age, and ethnicity are all likely to alter the influence of these alleles. [PMID 16905683]PMID 19508478] no influence on varicose veins
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