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rs3027172

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 2 Associated with alcohol dependence and increased drinking in response to psychosocial stress.
Make rs3027172(C;T)
Make rs3027172(T;T)
ReferenceGRCh38 38.1/141
Chromosome17
Position8152405
GenePER1
is asnp
is mentioned by
dbSNPrs3027172
ebirs3027172
HLIrs3027172
Exacrs3027172
Varsomers3027172
Maprs3027172
PheGenIrs3027172
hapmaprs3027172
1000 genomesrs3027172
hgdprs3027172
ensemblrs3027172
gopubmedrs3027172
geneviewrs3027172
scholarrs3027172
googlers3027172
pharmgkbrs3027172
gwascentralrs3027172
openSNPrs3027172
23andMers3027172
23andMe allrs3027172
SNP Nexus

SNPshotrs3027172
SNPdbers3027172
MSV3drs3027172
GWAS Ctlgrs3027172
GMAF0.1428
Max Magnitude2


[PMID 21828288] Effects of the Circadian Rhythm Gene Period 1 (Per1) on Psychosocial Stress-Induced Alcohol Drinking. (2011). Mice with the risk genotype (CC) showed enhanced alcohol consumption in response to social defeat stress relative to their wild-type litter mates (TT). An association with the frequency of heavy drinking in adolescents with the hPer1 promoter SNP rs3027172 and with psychosocial adversity was found. There was significant interaction between the rs3027172 genotype and psychosocial adversity on this drinking measure. Association of hPer1 rs3027172 with alcohol dependence was shown. Cortisol-induced transcriptional activation of hPer1 was reduced in human B-lymphoblastoid cells carrying the risk genotype of rs3027172. Binding affinity of the transcription factor Snail1 to the risk allele of the hPer1 SNP rs3027172 was also reduced.


[PMID 25677407] Clock genes in human alcohol abuse and comorbid conditions


[PMID 27065929] PER1 rs3027172 Genotype Interacts with Early Life Stress to Predict Problematic Alcohol Use, but Not Reward-Related Ventral Striatum Activity. (2016). Increasing evidence suggests that the circadian and stress regulatory systems contribute to alcohol use disorder (AUD) risk, which may partially arise through effects on reward-related neural function. The C allele of the PER1 rs3027172 single nucleotide polymorphism (SNP) reduces PER1 expression in cells incubated with cortisol and has been associated with increased risk for adult AUD and problematic drinking among adolescents exposed to high levels of familial psychosocial adversity. Using data from undergraduate students who completed the ongoing Duke Neurogenetics Study (DNS) (n = 665), we tested whether exposure to early life stress (ELS; Childhood Trauma Questionnaire) moderates the association between rs3027172 genotype and later problematic alcohol use (Alcohol Use Disorders Identification Test) as well as ventral striatum (VS) reactivity to reward (card-guessing task while functional magnetic resonance imaging data were acquired). Initial analyses found that PER1 rs3027172 genotype interacted with ELS to predict both problematic drinking and VS reactivity; minor C allele carriers, who were also exposed to elevated ELS reported greater problematic drinking and exhibited greater ventral striatum reactivity to reward-related stimuli. When gene × covariate and environment × covariate interactions were controlled for, the interaction predicting problematic alcohol use remained significant (p < 0.05, corrected) while the interaction predicting VS reactivity was no longer significant. These results extend our understanding of relationships between PER1 genotype, ELS, and problematic alcohol use, and serve as a cautionary tale on the importance of controlling for potential confounders in studies of moderation including gene × environment interactions.