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rs3077

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 2 1.8 times higher odds of having chronic hepatitis B
(T;T) 0 common in complete genomics
Make rs3077(C;T)
ReferenceGRCh38 38.1/141
Chromosome6
Position33065245
GeneHLA-DPA1
is asnp
is mentioned by
dbSNPrs3077
ebirs3077
HLIrs3077
Exacrs3077
Varsomers3077
Maprs3077
PheGenIrs3077
hapmaprs3077
1000 genomesrs3077
hgdprs3077
ensemblrs3077
gopubmedrs3077
geneviewrs3077
scholarrs3077
googlers3077
pharmgkbrs3077
gwascentralrs3077
openSNPrs3077
23andMers3077
23andMe allrs3077
SNP Nexus

SNPshotrs3077
SNPdbers3077
MSV3drs3077
GWAS Ctlgrs3077
GMAF0.3962
Max Magnitude2
? (C;C) (C;T) (T;T) 28

23andMe blog rs3077(A) and rs9277535(A) may reduce risk of Hepatitis B infection


[PMID 21346778OA-icon.png] Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver


[PMID 21750111] A Genome-Wide Association Study of Chronic Hepatitis B Identified Novel Risk Locus in a Japanese Population


[PMID 22363396OA-icon.png] HBV-Related Hepatocellular Carcinoma Susceptibility Gene KIF1B Is Not Associated with Development of Chronic Hepatitis B


[PMID 22448225OA-icon.png] A Common HLA-DPA1 Variant Is Associated with Hepatitis B Virus Infection but Fails to Distinguish Active from Inactive Caucasian Carriers


[PMID 22543033] Relationship between HLA-DP gene polymorphisms and clearance of chronic hepatitis B virus infections: Case-control study and meta-analysis


[PMID 22536334OA-icon.png] A Genome-Wide Homozygosity Association Study Identifies Runs of Homozygosity Associated with Rheumatoid Arthritis in the Human Major Histocompatibility Complex


[PMID 22105689] Genetic variants in HLA-DP/DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development.


[PMID 22737229OA-icon.png] Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean

[PMID 20436909OA-icon.png] The textile plot: a new linkage disequilibrium display of multiple-single nucleotide polymorphism genotype data.

[PMID 21310144] Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment.

[PMID 21402545OA-icon.png] A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese.

[PMID 21408128OA-icon.png] Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies.


[PMID 23326374OA-icon.png] Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients

GWAS snp
PMID [PMID 23760081]
Trait Chronic hepatitis B infection
Title A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
Risk Allele
P-val 5E-39
Odds Ratio 1.89 [1.69-2.08]


[PMID 24465836OA-icon.png] Genetic association of human leukocyte antigens with chronicity or resolution of hepatitis B infection in thai population


[PMID 23428460] Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: a two-stage study in Chinese women.


[PMID 23449268] HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B.


[PMID 23601003] Association of the rs3077 and rs9277535 polymorphisms in HLA-DP with hepatitis B virus infection and spontaneous clearance: a meta-analysis.


[PMID 24897020OA-icon.png] Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population


[PMID 25802187] Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B


[PMID 25449085] [Studies on the association of single nucleotide polymorphisms of HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection]


[PMID 25376093OA-icon.png] Association between single-nucleotide polymorphisms and early spontaneous hepatitis B virus e antigen seroconversion in children


[PMID 26387494] A randomized clinical trial of peginterferon alpha-2b with or without entecavir in patients with HBeAg-negative chronic hepatitis B: Role of host and viral factors associated with treatment response


[PMID 26634522] Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis.


[PMID 27252704] Relevance of HLA-DP/DQ and ICAM-1 SNPs among Ovarian Cancer Patients.


[PMID 27394003] Association of HLA-DP/DQ and STAT4 polymorphisms with ankylosing spondylitis in Southwest China.