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rs3095318

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 common/normal
(A;T) 3 In Japanese populations, associated with HLA-B*5801 allele and allopurinol side effects
(T;T) 3 In Japanese populations, associated with HLA-B*5801 allele and allopurinol side effects
ReferenceGRCh37.p5 37.3/135
Chromosome6
Position31088145
GeneCDSN, PSORS1C1
is asnp
is mentioned by
dbSNPrs3095318
ebirs3095318
HLIrs3095318
Exacrs3095318
Varsomers3095318
Maprs3095318
PheGenIrs3095318
hapmaprs3095318
1000 genomesrs3095318
hgdprs3095318
ensemblrs3095318
gopubmedrs3095318
geneviewrs3095318
scholarrs3095318
googlers3095318
pharmgkbrs3095318
gwascentralrs3095318
openSNPrs3095318
23andMers3095318
23andMe allrs3095318
SNP Nexus

SNPshotrs3095318
SNPdbers3095318
MSV3drs3095318
GWAS Ctlgrs3095318
GMAF0.1172
Max Magnitude3

The minor allele rs3095318(T), as defined on the minus strand, is reported to be associated in Japanese populations with the HLA-B*5801 allele and therefore susceptibility to severe side effects from taking allopurinol and perhaps other drugs. [PMID 16998491OA-icon.png]


[PMID 16642438OA-icon.png] Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.


GET Evidence
CDSN-M18L
aa_change Met18Leu
aa_change_short M18L
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.188257
summary