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rs3118470

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(T;T) 0
Make rs3118470(C;C)
Make rs3118470(C;T)
ReferenceGRCh38 38.1/142
Chromosome10
Position6059750
GeneIL2RA
is asnp
is mentioned by
dbSNPrs3118470
ebirs3118470
HLIrs3118470
Exacrs3118470
Varsomers3118470
Maprs3118470
PheGenIrs3118470
hapmaprs3118470
1000 genomesrs3118470
hgdprs3118470
ensemblrs3118470
gopubmedrs3118470
geneviewrs3118470
scholarrs3118470
googlers3118470
pharmgkbrs3118470
gwascentralrs3118470
openSNPrs3118470
23andMers3118470
23andMe allrs3118470
SNP Nexus

SNPshotrs3118470
SNPdbers3118470
MSV3drs3118470
GWAS Ctlgrs3118470
GMAF0.3186
Max Magnitude0
? (C;C) (C;T) (T;T) 28
Rs3118470
PubMed [PMID 17395754]
Affy Probeset SNP_A-8598463
Affy Orientation reverse
On GW 5.0 0
Alleles A/B A/G
Ancestral T
Population
Allele C
Case Freq.
Control Freq.
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All 1.28
Disease Type I Diabetes (T1D)


Neighborrs12722489
Distance299

rs3118470 increases susceptibility to Type I Diabetes 1.28 times for carriers of the C allele [PMID 17395754]


[PMID 19794070] A cis-Acting Regulatory Variant in the IL2RA Locus


[PMID 19956099OA-icon.png] The type I diabetes association of the IL2RA locus


[PMID 20615141] Association of the Protein Tyrosine Phosphatase Nonreceptor 22 Haplotypes with Autoimmune Thyroid Disease in the Japanese Population

GWAS snp
PMID [PMID 20596022OA-icon.png]
Trait Alopecia areata
Title Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
Risk Allele G
P-val 2E-12
Odds Ratio 1.41 [1.27-1.56]


[PMID 22085902OA-icon.png] Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis


[PMID 22211793] Polymorphic variants of the IL2RA gene and susceptibility to type 1 diabetes in the Polish population.

[PMID 18556337OA-icon.png] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).

[PMID 18776148OA-icon.png] Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms.

[PMID 18840781OA-icon.png] Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.

[PMID 19106270] Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population.

[PMID 19956101OA-icon.png] Overview of the Rapid Response data.

[PMID 19956106OA-icon.png] Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.

GWAS snp
PMID [PMID 21833088OA-icon.png]
Trait Multiple sclerosis
Title Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Risk Allele G
P-val 3E-11
Odds Ratio 1.12 [1.1-1.13]


[PMID 22213266] Functional polymorphism rs7072793 C > T affect individual susceptibility to breast cancer by modulating CD25 transcription activity.