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rs3129878

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) normal risk for infertility in Chinese men
(A;C) 1.2 1.36 slightly higher risk for infertility in Chinese men
(C;C) 1.3 >1.36 higher risk for infertility in Chinese men
ReferenceGRCh38 38.1/141
Chromosome6
Position32440958
GeneHLA-DRA
is asnp
is mentioned by
dbSNPrs3129878
ebirs3129878
HLIrs3129878
Exacrs3129878
Varsomers3129878
Maprs3129878
PheGenIrs3129878
hapmaprs3129878
1000 genomesrs3129878
hgdprs3129878
ensemblrs3129878
gopubmedrs3129878
geneviewrs3129878
scholarrs3129878
googlers3129878
pharmgkbrs3129878
gwascentralrs3129878
openSNPrs3129878
23andMers3129878
23andMe allrs3129878
SNP Nexus

SNPshotrs3129878
SNPdbers3129878
MSV3drs3129878
GWAS Ctlgrs3129878
GMAF0.3108
Max Magnitude1.3
rs3129878 is a SNP in the HLA gene region. It has been associated with slightly (~30%) higher risk for azoospermia (lack of sperm) and thus male infertility in both Chinese and Japanese men.[PMID 22541561OA-icon.png][PMID 23934009]
? (A;A) (A;C) (C;C) 28

[PMID 23934009] HLA-DPB1*04:01 allele is associated with non-obstructive azoospermia in Japanese patients


[PMID 19846760OA-icon.png] Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.


[PMID 22541561OA-icon.png] A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.