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rs3131296

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 normal risk for developing schizophrenia
(A;G) 1.2 1.2x increased risk for schizophrenia
(G;G) 1.4 1.4x increased risk for schizophrenia
ReferenceGRCh38 38.1/141
Chromosome6
Position32205216
GeneNOTCH4
is asnp
is mentioned by
dbSNPrs3131296
ebirs3131296
HLIrs3131296
Exacrs3131296
Varsomers3131296
Maprs3131296
PheGenIrs3131296
hapmaprs3131296
1000 genomesrs3131296
hgdprs3131296
ensemblrs3131296
gopubmedrs3131296
geneviewrs3131296
scholarrs3131296
googlers3131296
pharmgkbrs3131296
gwascentralrs3131296
openSNPrs3131296
23andMers3131296
23andMe allrs3131296
SNP Nexus

SNPshotrs3131296
SNPdbers3131296
MSV3drs3131296
GWAS Ctlgrs3131296
GMAF0.06887
Max Magnitude1.4
? (A;A) (A;G) (G;G) 28
23andMe blog schizophrenia
  • rs3131296(C) increased the odds of schizophrenia by 1.19x
  • rs12807809(T) increased the odds of schizophrenia by 1.15x
  • rs9960767(C) increased the odds of schizophrenia by 1.23 times.

[PMID 20673877] A study of ~2,500 Han Chinese patients with schizophrenia did find rs3131296 to be significantly associated in this population.

GWAS snp
PMID [PMID 19571808OA-icon.png]
Trait Schizophrenia
Title Common variants conferring risk of schizophrenia
Risk Allele G
P-val 2E-10
Odds Ratio 1.19 [NR]


[PMID 18204098] Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.


[PMID 19343178OA-icon.png] Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.


[PMID 23053058] Search for schizophrenia susceptibility variants at the HLA-DRB1 locus among a British population


GET Evidence
rs3131296
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.109375
summary



[PMID 22005930OA-icon.png] Genome-wide association study of Alzheimer's disease with psychotic symptoms.


[PMID 25142293] Association between the NOTCH4 gene rs3131296 polymorphism with schizophrenia risk in the Chinese Zhuang population and Chinese Han population