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rs3132293

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) normal
(A;G) decreased risk of Alzheimer's disease
(G;G) decreased risk of Alzheimer's disease
ReferenceGRCh38 38.1/141
Chromosome9
Position134433976
GeneRXRA
is asnp
is mentioned by
dbSNPrs3132293
ebirs3132293
HLIrs3132293
Exacrs3132293
Varsomers3132293
Maprs3132293
PheGenIrs3132293
hapmaprs3132293
1000 genomesrs3132293
hgdprs3132293
ensemblrs3132293
gopubmedrs3132293
geneviewrs3132293
scholarrs3132293
googlers3132293
pharmgkbrs3132293
gwascentralrs3132293
openSNPrs3132293
23andMers3132293
23andMe allrs3132293
SNP Nexus

SNPshotrs3132293
SNPdbers3132293
MSV3drs3132293
GWAS Ctlgrs3132293
GMAF0.1882
Max Magnitude
A screen of SNPs in the RXRA gene in 405 Alzheimer's disease patients (mean age 74 +/- 9 years) suggests that the rs3132293(G) allele (in dbSNP orientation) is associated with lower risk for the disease.[PMID 18544046]

However, it should be noted that (1) this allele is quite common, (2) there was a significant difference in the % of females (79%) in the patient population compared to the control population (57%), and (3) the magnitude of associated changes in cerebral cholesterol is not high.


[PMID 19374686OA-icon.png] RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism