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rs314276

From SNPedia

Orientationplus
Stabilizedplus
Make rs314276(A;A)
Make rs314276(A;C)
Make rs314276(C;C)
ReferenceGRCh38 38.1/141
Chromosome6
Position104960124
GeneLIN28B
is asnp
is mentioned by
dbSNPrs314276
ebirs314276
HLIrs314276
Exacrs314276
Varsomers314276
Maprs314276
PheGenIrs314276
hapmaprs314276
1000 genomesrs314276
hgdprs314276
ensemblrs314276
gopubmedrs314276
geneviewrs314276
scholarrs314276
googlers314276
pharmgkbrs314276
gwascentralrs314276
openSNPrs314276
23andMers314276
23andMe allrs314276
SNP Nexus

SNPshotrs314276
SNPdbers314276
MSV3drs314276
GWAS Ctlgrs314276
GMAF0.3641
Max Magnitude
? (A;A) (A;C) (C;C) 28
23andMe blog

rs314276 or the equivalent rs314263(T) yields

  • Female
    • menarche about six weeks earlier
    • 1.2x accelerated breast development and a faster rate of increase in height and weight.
    • a reduction in adult height of about 0.15 inches.
  • Male
    • 1.26 greater odds of advanced voice breaking at age 15
    • 1.19 times greater odds of advanced pubic hair at age 13
    • faster rate of growth at age 10 and about a tenth of an inch less in adult height.
GWAS snp
PMID [PMID 19448623OA-icon.png]
Trait Menarche (age at onset)
Title Genetic variation in LIN28B is associated with the timing of puberty
Risk Allele C
P-val 4E-16
Odds Ratio 0.14 [0.11-0.17] years younger
OMIM612882
Desc
Variant
Relatedalso
[PMID 20962026OA-icon.png] Associations between the Pubertal Timing-Related Variant in LIN28B and BMI Vary Across the Life Course


[PMID 22822098] Functional Study of Risk Loci of Stem Cell-associated Gene Lin-28B and Associations with Disease Survival Outcomes in Epithelial Ovarian Cancer


GET Evidence
rs314276
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.641304
summary



GWAS snp
PMID [PMID 24770850OA-icon.png]
Trait Puberty onset
Title Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.
Risk Allele C
P-val 2E-8
Odds Ratio .08 [0.053-0.107] unit increase