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rs3211938

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(T;T) 0 common in complete genomics
Make rs3211938(G;G)
Make rs3211938(G;T)
ReferenceGRCh38 38.1/141
Chromosome7
Position80671133
GeneCD36
is asnp
is mentioned by
dbSNPrs3211938
ebirs3211938
HLIrs3211938
Exacrs3211938
Varsomers3211938
Maprs3211938
PheGenIrs3211938
hapmaprs3211938
1000 genomesrs3211938
hgdprs3211938
ensemblrs3211938
gopubmedrs3211938
geneviewrs3211938
scholarrs3211938
googlers3211938
pharmgkbrs3211938
gwascentralrs3211938
openSNPrs3211938
23andMers3211938
23andMe allrs3211938
SNP Nexus

SNPshotrs3211938
SNPdbers3211938
MSV3drs3211938
GWAS Ctlgrs3211938
GMAF0.03306
Max Magnitude0
? (G;G) (G;T) (T;T) 28
[PMID 18305138OA-icon.png] 2020 African Americans. rs3211938, previously shown to influence malaria susceptibility, is documented to result in CD36 deficiency in a homozygous subject. This SNP conferred protection against the Metabolic Syndrome (p=0.0012, OR= 0.61, 95%CI: 0.46-0.82), increased high-density lipoprotein cholesterol, HDL-C (p=0.00018), and decreased triglycerides (p=0.0059)


[PMID 19403559OA-icon.png] Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes

OMIM173510
DescCD36 ANTIGEN; CD36
Variant
Relatedalso
OMIM605552
Desc
Variant
Relatedalso
[PMID 17668374OA-icon.png] Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants.


[PMID 19055786OA-icon.png] Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India.


[PMID 19064790OA-icon.png] Predictive genomics of cardioembolic stroke.


[PMID 19200524OA-icon.png] A genome-wide survey of the prevalence and evolutionary forces acting on human nonsense SNPs.


[PMID 20585394OA-icon.png] Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children.


[PMID 20935172OA-icon.png] Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile.


GET Evidence
CD36-Y325X
aa_change Tyr325Stop
aa_change_short Y325X
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.0277933
summary



[PMID 23844572] CD36 Gene Variants and Their Association with Type 2 Diabetes in an Indian Population


[PMID 25565374] CD36 Gene Variants in Early Prediction of Type 2 Diabetes Mellitus