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rs324640

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A)
(A;G)
(G;G)
ReferenceGRCh38 38.1/141
Chromosome7
Position137004249
GeneCHRM2, LOC349160
is asnp
is mentioned by
dbSNPrs324640
ebirs324640
HLIrs324640
Exacrs324640
Varsomers324640
Maprs324640
PheGenIrs324640
hapmaprs324640
1000 genomesrs324640
hgdprs324640
ensemblrs324640
gopubmedrs324640
geneviewrs324640
scholarrs324640
googlers324640
pharmgkbrs324640
gwascentralrs324640
openSNPrs324640
23andMers324640
23andMe allrs324640
SNP Nexus

SNPshotrs324640
SNPdbers324640
MSV3drs324640
GWAS Ctlgrs324640
GMAF0.4325
Max Magnitude
? (A;A) (A;G) (G;G) 28
SNPs in the SNAP25 gene were initially [PMID 17160701] linked to intelligence but have failed to replicate [PMID 19418213].

While now suspect, the original work can be found in [PMID 17160701] and [PMID 17081262] or this pdf poster show association between the CHRM2 gene and intelligence . In this study of ~300 Caucasians, the (G;G) genotype appeared to typically have a 4 point higher IQ than the (A;G) genotype, which had a 4 point higher IQ (on average) than the (A;A) genotype. A nearby SNP, rs324650, showed similar results to rs324640, and was in linkage disequilibrium (r2 = 0.90) with it. [PMID 17081262]


[PMID 18979273] Acetylcholine receptor M2 gene variants, heart rate recovery, and risk of cardiac death after an acute myocardial infarction


[PMID 16501017] Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 (CHRM2) gene polymorphism.


[PMID 17996044OA-icon.png] Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study.


[PMID 18634760OA-icon.png] Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.