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rs324981

From SNPedia

Orientationplus
Stabilizedplus
Make rs324981(A;A)
Make rs324981(A;T)
Make rs324981(T;T)
ReferenceGRCh38 38.1/141
Chromosome7
Position34778501
GeneNPSR1, NPSR1-AS1
is asnp
is mentioned by
dbSNPrs324981
ebirs324981
HLIrs324981
Exacrs324981
Varsomers324981
Maprs324981
PheGenIrs324981
hapmaprs324981
1000 genomesrs324981
hgdprs324981
ensemblrs324981
gopubmedrs324981
geneviewrs324981
scholarrs324981
googlers324981
pharmgkbrs324981
gwascentralrs324981
openSNPrs324981
23andMers324981
23andMe allrs324981
SNP Nexus

SNPshotrs324981
SNPdbers324981
MSV3drs324981
GWAS Ctlgrs324981
GMAF0.4826
Max Magnitude
? (A;A) (A;T) (T;T) 28
OMIM608595
DescASTHMA SUSCEPTIBILITY 2
Variant0001
Relatedalso
asthma related

influences sleep patterns [1]


[PMID 20603625] Neuropeptide S receptor gene - converging evidence for a role in panic disorder


[PMID 21525857OA-icon.png] Neuropeptide-S (NPS) Receptor Genotype Modulates Basolateral Amygdala Responsiveness to Aversive Stimuli


[PMID 22216302OA-icon.png] Multiple Polymorphisms Affect Expression and Function of the Neuropeptide S Receptor (NPSR1)


ClinVar
Risk rs324981(T;T)
Alt rs324981(T;T)
Reference rs324981(A;A)
Significance Other
Disease Asthma-related traits
Variation info
Gene NPSR1-AS1 NPSR1
CLNDBN Asthma-related traits, susceptibility to, 2
Reversed 0
HGVS NC_000007.13:g.34818113A>T
CLNSRC OMIM Allelic Variant
CLNACC RCV000002276.3,



[PMID 16522461] G protein-coupled receptor 154 gene polymorphism is associated with airway hyperresponsiveness to methacholine in a Chinese population.


[PMID 17702965OA-icon.png] Comprehensive testing of positionally cloned asthma genes in two populations.


[PMID 17903308OA-icon.png] Genome-wide association of sleep and circadian phenotypes.


[PMID 18340359OA-icon.png] Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy.


[PMID 20179762OA-icon.png] Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis.


[PMID 22078257] The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response.


[PMID 22399050] Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation.


GET Evidence
NPSR1-N107I
aa_change Asn107Ile
aa_change_short N107I
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.489403
summary



[PMID 23680103] The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) influences age at onset of obsessive-compulsive disorder


[PMID 23319044] Neuropeptide S receptor (NPSR1) gene variation modulates response inhibition and error monitoring.


[PMID 23663310OA-icon.png] Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.


[PMID 24754478] Neuropeptide S receptor gene variant and environment: contribution to alcohol use disorders and alcohol consumption


[PMID 24800784] A functional variant in the neuropeptide S receptor 1 gene moderates the influence of urban upbringing on stress processing in the amygdala


[PMID 24896296OA-icon.png] Genetic Association of Objective Sleep Phenotypes with a Functional Polymorphism in the Neuropeptide S Receptor Gene


[PMID 25744621] Further evidence for the association of the NPSR1 gene A/T polymorphism (Asn107Ile) with impulsivity and hyperactivity