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rs334558

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 later onset of BP
(A;G) later onset of BP
(G;G) common
ReferenceGRCh38 38.1/141
Chromosome3
Position120094435
GeneGSK3B, LOC100996310
is asnp
is mentioned by
dbSNPrs334558
ebirs334558
HLIrs334558
Exacrs334558
Varsomers334558
Maprs334558
PheGenIrs334558
hapmaprs334558
1000 genomesrs334558
hgdprs334558
ensemblrs334558
gopubmedrs334558
geneviewrs334558
scholarrs334558
googlers334558
pharmgkbrs334558
gwascentralrs334558
openSNPrs334558
23andMers334558
23andMe allrs334558
SNP Nexus

SNPshotrs334558
SNPdbers334558
MSV3drs334558
GWAS Ctlgrs334558
GMAF0.4747
Max Magnitude0
? (A;A) (A;G) (G;G) 28
Although not associated with increased risk for developing bipolar disorder, amongst those with it, the (G) allele of this SNP has been reported to have a somewhat protective effect in that individuals who have a (G) allele develop bipolar disorder at a later age than those with the more common (A;A) genotypes. [PMID 15351432, PMID 14729229]

Also known as the -50T/C SNP from this GSK3-beta (GSK3B) gene.

may effect lithium treatment response - [PMID 17628506] C allele carriers showed considerably greater response with lithium treatment, with remissions of 56.25% after 4 weeks compared to 31% for T/T carriers


[PMID 19573950] GSK3beta polymorphisms, MAPT H1 haplotype and Parkinson's disease in a Greek cohort

OMIM605004
DescGLYCOGEN SYNTHASE KINASE 3-BETA; GSK3B
Variant
Relatedalso



[PMID 20055739] Role of glycogen synthase kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus

[PMID 21159074] SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study


[PMID 22119086] Gene-gene interaction of glycogen synthase kinase 3-? and serotonin transporter on human antidepressant response to sleep deprivation


[PMID 22815195] GSK3β reduces risk of sporadic Parkinson's disease in ethnic Chinese


[PMID 19154537] Epistasis between tau phosphorylation regulating genes (CDK5R1 and GSK-3beta) and Alzheimer's disease risk.


[PMID 20113358] Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-beta activity.


[PMID 21443865] Association analysis of GSK3B and MAPT polymorphisms with Alzheimer's disease in Han Chinese.


[PMID 21527318] GSK3beta genetic variability in patients with Multiple Sclerosis.


[PMID 23021822] Glycogen synthase kinase 3β gene polymorphisms may be associated with bipolar I disorder and the therapeutic response to lithium


GET Evidence
rs334558
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.547619
summary



[PMID 23440732] GSK-3β Polymorphism Discriminates Bipolar Disorder and Schizophrenia: A Systematic Meta-Analysis


[PMID 21130530] Role of tau kinases (CDK5R1 and GSK3B) in Parkinson's disease: a study from India


[PMID 22990942OA-icon.png] Lithium and GSK3-beta promoter gene variants influence white matter microstructure in bipolar disorder.


[PMID 23030648OA-icon.png] Possible association of the GSK3beta gene with the anxiety symptoms of major depressive disorder and P300 waveform.


[PMID 23628795] The association between glycogen synthase kinase 3 beta polymorphisms and Parkinson's disease susceptibility: a meta-analysis.


[PMID 24929537] Meta-analysis demonstrates lack of association of the GSK3B -50C/T polymorphism with risk of bipolar disorder


[PMID 24779391OA-icon.png] MAPT rs242562 and GSK3B rs334558 are associated with Parkinson's Disease in central China