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rs33980500

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common on affy axiom data
(C;T) 1.6 1.6x increase in risk for psoriatic arthritis
(T;T) 2 1.6x increase in risk for psoriatic arthritis
ReferenceGRCh38 38.1/141
Chromosome6
Position111592059
GeneTRAF3IP2, TRAF3IP2-AS1
is asnp
is mentioned by
dbSNPrs33980500
ebirs33980500
HLIrs33980500
Exacrs33980500
Varsomers33980500
Maprs33980500
PheGenIrs33980500
hapmaprs33980500
1000 genomesrs33980500
hgdprs33980500
ensemblrs33980500
gopubmedrs33980500
geneviewrs33980500
scholarrs33980500
googlers33980500
pharmgkbrs33980500
gwascentralrs33980500
openSNPrs33980500
23andMers33980500
23andMe allrs33980500
SNP Nexus

SNPshotrs33980500
SNPdbers33980500
MSV3drs33980500
GWAS Ctlgrs33980500
GMAF0.08173
Max Magnitude2

[PMID 25651891OA-icon.png] reports rs33980500, with risk/non-risk alleles T/C, has an odds ratio of 1.6 (p=2.65e−16) for psoriatic arthritis based on a case/control study of ~2,000 patients.


[PMID 20953186OA-icon.png] Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis

GWAS snp
PMID [PMID 20953188OA-icon.png]
Trait
Title Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
Risk Allele T
P-val 1E-16
Odds Ratio None None


[PMID 22513239OA-icon.png] Identification of low frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization


[PMID 22445837] TRAF3IP2 gene is associated with cutaneous extraintestinal manifestations in Inflammatory Bowel Disease.


GET Evidence
TRAF3IP2-D10N
aa_change Asp10Asn
aa_change_short D10N
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.0981595
summary



[PMID 23116200OA-icon.png] New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis


[PMID 24005976OA-icon.png] Common variants of ZNF750, RPTOR and TRAF3IP2 genes and psoriasis risk


[PMID 23836313] TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development.


ClinVar
Risk rs33980500(T;T)
Alt rs33980500(T;T)
Reference rs33980500(C;C)
Significance Other
Disease Psoriasis susceptibility 13
Variation info
Gene TRAF3IP2 TRAF3IP2-AS1
CLNDBN Psoriasis susceptibility 13
Reversed 0
HGVS NC_000006.11:g.111913262C>T
CLNSRC OMIM Allelic Variant
CLNACC RCV000023605.6,