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rs34210653

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 normal risk
(C;T) 1.6x increased risk for heart disease
(T;T) normal risk
ReferenceGRCh38 38.1/142
Chromosome17
Position4632019
GeneALOX15
is asnp
is mentioned by
dbSNPrs34210653
ebirs34210653
HLIrs34210653
Exacrs34210653
Varsomers34210653
Maprs34210653
PheGenIrs34210653
hapmaprs34210653
1000 genomesrs34210653
hgdprs34210653
ensemblrs34210653
gopubmedrs34210653
geneviewrs34210653
scholarrs34210653
googlers34210653
pharmgkbrs34210653
gwascentralrs34210653
openSNPrs34210653
23andMers34210653
23andMe allrs34210653
SNP Nexus

SNPshotrs34210653
SNPdbers34210653
MSV3drs34210653
GWAS Ctlgrs34210653
GMAF0.01469
Max Magnitude0
rs34210653 is a SNP in the ALOX15 gene, either encoding a threonine or a methionine at position 560 of the corresponding protein. This SNP is also known as T560M; the more common (C) allele encodes the threonine, and the rarer (T) allele encodes the methionine.

In mice, this protein appears to promote atherosclerosis, and mice completely lacking the entire gene are free of atherosclerosis. In contrast, rs34210653(T;T) humans, who effectively have a non-functioning variant, do not show a statistically significant decreased risk for coronary artery disease. And rs34210653(C;T) heterozygotes an increased risk of heart disease (adjusted odds ratio 1.62, p=0.02).[PMID 17959182OA-icon.png]

Neighborrs916055
Distance480
Neighborrs2619112
Distance71
[PMID 19046748OA-icon.png] Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.


GET Evidence
ALOX15-T560M
aa_change Thr560Met
aa_change_short T560M
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.012177
summary



[PMID 23906684] Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants