|| Duffy FY(bwk) blood group, and possible malarial resistance
|| carrier of a Duffy weak allele, and possible malarial resistance
|| common in clinvar
rs34599082, also known as c.265C>T, p.Arg89Cys and R89C, represents an uncommon variant in the DARC gene on chromosome 1, which is better known for it's role as part of the Duffy blood group (antigen) on red blood cells.
Found in ~1% of the population, the rs34599082(A) allele (as represented in dbSNP/minus orientation) encodes the Duffy blood group FY(bwk) phenotype, which is also known as FY-weak. This allele results in lower amounts of DARC protein, and thus lower antigen expression and chemokine binding ability.
This variant may offer some protection against infection by malaria.[PMID 11369664]
[PMID 21257350] DNA-based methods in the immunohematology reference laboratory.