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rs34743033

From SNPedia

Orientationplus
Stabilizedplus
Make rs34743033(C;C)
Make rs34743033(C;T)
Make rs34743033(T;T)
ReferenceGRCh37.p2 37.2/134
Chromosome18
Position657646
GeneC18orf56, TYMS
is asnp
is mentioned by
dbSNPrs34743033
ebirs34743033
HLIrs34743033
Exacrs34743033
Varsomers34743033
Maprs34743033
PheGenIrs34743033
hapmaprs34743033
1000 genomesrs34743033
hgdprs34743033
ensemblrs34743033
gopubmedrs34743033
geneviewrs34743033
scholarrs34743033
googlers34743033
pharmgkbrs34743033
gwascentralrs34743033
openSNPrs34743033
23andMers34743033
23andMe allrs34743033
SNP Nexus

SNPshotrs34743033
SNPdbers34743033
MSV3drs34743033
GWAS Ctlgrs34743033
Max Magnitude
response to chemotherapy http://www.pharmgkb.org/search/annotatedGene/tyms/variant.jsp

(C) more favorable therapeutic response in advanced colorectal cancer and toxicity [PMID 10652619] [PMID 17716232]

(G) allele of this SNP is associated with grade 3 to 4 neutropenia and diarrhea 5-fluorouracil Neutropenia [PMID 16818689]






[PMID 22825513] Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer

[PMID 23652803] Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity and outcome in childhood acute lymphoblastic leukemia

[PMID 23401104] Folate-genetics and colorectal neoplasia: what we know and need to know next

[PMID 24554028] Thymidylate synthase polymorphisms are associated to therapeutic outcome of advanced non-small cell lung cancer patients treated with platinum-based chemotherapy