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rs353016

From SNPedia

Merged intors352054
Orientationplus
Stabilizedplus
Make rs353016(T;T)
Make rs353016(C;T)
Make rs353016(C;C)
ReferenceGRCh38 38.1/141
Chromosome4
Position74015033
GeneSNAP25
is asnp
is mentioned by
dbSNPrs353016
ebirs353016
HLIrs353016
Exacrs353016
Varsomers353016
Maprs353016
PheGenIrs353016
hapmaprs353016
1000 genomesrs353016
hgdprs353016
ensemblrs353016
gopubmedrs353016
geneviewrs353016
scholarrs353016
googlers353016
pharmgkbrs353016
gwascentralrs353016
openSNPrs353016
23andMers353016
23andMe allrs353016
SNP Nexus

SNPshotrs353016
SNPdbers353016
MSV3drs353016
GWAS Ctlgrs353016
StatusMerged into rs352054
Max Magnitude
SNPs in the SNAP25 gene were initially [PMID 17160701] linked to intelligence but have failed to replicate [PMID 19418213].

While now suspect, the original work can be found in [PMID 16801949].

The (T;T) genotype averages almost 3 PIQ points higher than the (C;T) genotype, which averages almost 3 PIQ points higher than the (C;C) genotype.[PMID 17908175]

rs353016 is in close linkage with rs363050, with r2 = 0.98, such that the rs363050(A) allele typically is linked to the rs353016(T) allele. For SNPs rs363039 - rs363043 - rs353016, respectively, the haplotype C-T-T is most associated with higher intelligence in children, whereas the haplotype C-C-T is most associated in adults (SNPs oriented as in dbSNP). [PMID 17908175]