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rs35599367

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 common in complete genomics
Make rs35599367(C;T)
Make rs35599367(T;T)
ReferenceGRCh38 38.1/141
Chromosome7
Position99768693
GeneCYP3A4
is asnp
is mentioned by
dbSNPrs35599367
ebirs35599367
HLIrs35599367
Exacrs35599367
Varsomers35599367
Maprs35599367
PheGenIrs35599367
hapmaprs35599367
1000 genomesrs35599367
hgdprs35599367
ensemblrs35599367
gopubmedrs35599367
geneviewrs35599367
scholarrs35599367
googlers35599367
pharmgkbrs35599367
gwascentralrs35599367
openSNPrs35599367
23andMers35599367
23andMe allrs35599367
SNP Nexus

SNPshotrs35599367
SNPdbers35599367
MSV3drs35599367
GWAS Ctlgrs35599367
GMAF0.02158
Max Magnitude0

[PMID 20386561OA-icon.png] Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs

[PMID 21903774] A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients

[PMID 21902502] Effect of a new functional CYP3A4 polymorphism on calcineurin inhibitors dose requirements and trough blood levels in stable renal transplant patients [PMID 21946898] Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study.


[PMID 22388796] The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients.

[PMID 23252948] CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy

[PMID 23574377] Severe acute nephrotoxicity in a kidney transplant patient despite low tacrolimus levels: a possible interaction between donor and recipient genetic polymorphisms [PMID 23501331] Effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and CYP3A activity in hypercholeresterolemic patients.

[PMID 26488616] CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing