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rs356168

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 slight decrease in risk for Parkinson's disease
(A;G) 2 slight decrease in risk for Parkinson's disease
(G;G) 0 common
ReferenceGRCh38.p2 38.2/147
Chromosome4
Position89753280
GeneSNCA
is asnp
is mentioned by
dbSNPrs356168
ebirs356168
HLIrs356168
Exacrs356168
Varsomers356168
Maprs356168
PheGenIrs356168
hapmaprs356168
1000 genomesrs356168
hgdprs356168
ensemblrs356168
gopubmedrs356168
geneviewrs356168
scholarrs356168
googlers356168
pharmgkbrs356168
gwascentralrs356168
openSNPrs356168
23andMers356168
23andMe allrs356168
SNP Nexus

SNPshotrs356168
SNPdbers356168
MSV3drs356168
GWAS Ctlgrs356168
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs356168 represents a common SNP in an untranslated region of the SNCA gene on chromosome 4.

The rs356168(A) allele yields a slightly reduced risk for Parkinson's disease compared to the more common (G) allele.[PMID 25064009OA-icon.png]

An in vitro study of the effect of the rs356168(G) allele concludes it leads to increased transcription of the corresponding SNCA allele, which the authors feel is a credible explanation for the slight increase in risk for Parkinson's.[PMID 27096366]