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rs356219

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G) 1.3 1.3x increased risk for Parkinson's disease
(G;G) 1.6 1.6x increased risk for Parkinson's disease
ReferenceGRCh38 38.1/141
Chromosome4
Position89716450
GeneSNCA
is asnp
is mentioned by
dbSNPrs356219
ebirs356219
HLIrs356219
Exacrs356219
Varsomers356219
Maprs356219
PheGenIrs356219
hapmaprs356219
1000 genomesrs356219
hgdprs356219
ensemblrs356219
gopubmedrs356219
geneviewrs356219
scholarrs356219
googlers356219
pharmgkbrs356219
gwascentralrs356219
openSNPrs356219
23andMers356219
23andMe allrs356219
SNP Nexus

SNPshotrs356219
SNPdbers356219
MSV3drs356219
GWAS Ctlgrs356219
GMAF0.4922
Max Magnitude1.6
? (A;A) (A;G) (G;G) 28
rs356219, a tagging SNP in the SNCA gene for a Parkinson's disease associated haplotype, predicts the amount of SNCA (alpha-synuclein) mRNA found in post mortem substantia nigra and cerebellum brain tissue. [PMID 18122487]

[PMID 21425343OA-icon.png] replicates the association of rs356219 with late-onset Parkinson's disease, calculating an odds ratio of 1.3 (CI: 1.13 - 1.5, p=2x10e-4) per rs356219(G) allele among the 1145 patients from northern Spain studied.


[PMID 18485051] Multiple alpha-synuclein gene polymorphisms are associated with Parkinson's disease in a Norwegian population.

OMIM157140
DescMICROTUBULE-ASSOCIATED PROTEIN TAU; MAPT
Variant
Relatedalso
OMIM163890
DescSYNUCLEIN, ALPHA; SNCA
Variant
Relatedalso
[PMID 21060011OA-icon.png] SNCA Variant Associated With Parkinson Disease and Plasma {alpha}-Synuclein Level

[PMID 21159074] SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study

GWAS snp
PMID [PMID 21292315OA-icon.png]
Trait
Title Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies
Risk Allele G
P-val 2E-47
Odds Ratio 1.2900 [1.25-1.33]


[PMID 22349157] SNP rs356219 of the ?-synuclein (SNCA) gene is associated with Parkinson's disease in a Chinese Han population


[PMID 22669510] Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants

GWAS snp
PMID [PMID 22438815OA-icon.png]
Trait
Title Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
Risk Allele
P-val 6E-65
Odds Ratio 1.2900 None

[PMID 15637659OA-icon.png] Linkage disequilibrium patterns and tagSNP transferability among European populations.

[PMID 17683088] Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.

[PMID 18162487] Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.

[PMID 18606870] Cerebellar alpha-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material.

[PMID 18985386OA-icon.png] Genomewide association study for susceptibility genes contributing to familial Parkinson disease.

[PMID 19063963OA-icon.png] Genetic susceptibility in Parkinson's disease.

[PMID 19771175OA-icon.png] Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.

[PMID 19834617OA-icon.png] Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.

[PMID 21391235OA-icon.png] Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.

[PMID 22425546] SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese.


[PMID 23737253] SNCA rs356219 variant increases risk of sporadic Parkinson's disease in Ethnic Chinese


[PMID 23962496OA-icon.png] The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants


[PMID 23674386] SNCA: major genetic modifier of age at onset of Parkinson's disease.


[PMID 25656566] Alpha-synuclein (SNCA) polymorphisms and susceptibility to Parkinson's disease: A meta-analysis


[PMID 27538639] SNCA rs356182 variant increases risk of sporadic Parkinson's disease in ethnic Chinese.