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rs35667974

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 common in complete genomics
Make rs35667974(A;G)
Make rs35667974(G;G)
ReferenceGRCh38 38.1/142
Chromosome2
Position162268127
GeneIFIH1
is asnp
is mentioned by
dbSNPrs35667974
ebirs35667974
HLIrs35667974
Exacrs35667974
Varsomers35667974
Maprs35667974
PheGenIrs35667974
hapmaprs35667974
1000 genomesrs35667974
hgdprs35667974
ensemblrs35667974
gopubmedrs35667974
geneviewrs35667974
scholarrs35667974
googlers35667974
pharmgkbrs35667974
gwascentralrs35667974
openSNPrs35667974
23andMers35667974
23andMe allrs35667974
SNP Nexus

SNPshotrs35667974
SNPdbers35667974
MSV3drs35667974
GWAS Ctlgrs35667974
GMAF0.003214
Max Magnitude0
rs35667974, also known as Ile923Val, is a SNP in the interferon induced with helicase C domain 1 IFIH1 gene.

A recent study apparently found this SNP had the strongest association with type-1 diabetes; however, in a study of 3,000 European multiple sclerosis patients, no association was seen.[PMID 20116863OA-icon.png]



[PMID 20668468OA-icon.png] Carriers of rare missense variants in IFIH1 are protected from psoriasis

OMIM610155
Desc
Variant
Relatedalso


[PMID 20736039] Loss-of-function mutations E6 27X and I923V of IFIH1 are associated with lower poly(I:C)-induced interferon-? production in peripheral blood mononuclear cells of type 1 diabetes patients


[PMID 22110759OA-icon.png] Polymorphisms in the Innate Immune IFIH1 Gene, Frequency of Enterovirus in Monthly Fecal Samples during Infancy, and Islet Autoimmunity


[PMID 19961590OA-icon.png] The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease.


[PMID 23144876OA-icon.png] Enterovirus RNA in Peripheral Blood May Be Associated with the Variants of rs1990760, a Common Type 1 Diabetes Associated Polymorphism in IFIH1