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rs35677470

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.3 Higher risk for scleroderma
(A;G) 1.2 2x higher risk for scleroderma
(G;G) 0 normal/common
ReferenceGRCh38 38.1/142
Chromosome3
Position58197909
GeneDNASE1L3
is asnp
is mentioned by
dbSNPrs35677470
ebirs35677470
HLIrs35677470
Exacrs35677470
Varsomers35677470
Maprs35677470
PheGenIrs35677470
hapmaprs35677470
1000 genomesrs35677470
hgdprs35677470
ensemblrs35677470
gopubmedrs35677470
geneviewrs35677470
scholarrs35677470
googlers35677470
pharmgkbrs35677470
gwascentralrs35677470
openSNPrs35677470
23andMers35677470
23andMe allrs35677470
SNP Nexus

SNPshotrs35677470
SNPdbers35677470
MSV3drs35677470
GWAS Ctlgrs35677470
Max Magnitude1.3
rs35677470, also known as R206C, is a missense SNP in the deoxyribonuclease I-like 3 [DNASEIL3] gene on chromosome 3.

A study of ~500 Australian patients with scleroderma concluded that the rarer rs35677470(A) allele was associated with higher risk for anti-centromere antibody (ACA) positive cases (odds ratio 2.36, p=2.3x10e-10). There was no risk associated with ACA-negative scleroderma.[PMID 25332064OA-icon.png]