|| Higher risk for scleroderma
|| 2x higher risk for scleroderma
, also known as R206C, is a missense SNP in the deoxyribonuclease I-like 3 [DNASEIL3] gene on chromosome 3.
A study of ~500 Australian patients with scleroderma concluded that the rarer rs35677470(A) allele was associated with higher risk for anti-centromere antibody (ACA) positive cases (odds ratio 2.36, p=2.3x10e-10). There was no risk associated with ACA-negative scleroderma.[PMID 25332064]