|(G;G)||0||common in complete genomics|
For interstitial pneumonia, the odds ratio for heterozygotes was 6.8 (CI: 3.9 - 12.0) and for homozygotes, 20.8 (CI: 3.8 - 113.7).[PMID 21506741]
For pulmonary fibrosis, the reported odds ratios for heterozygotes and homozygotes in one study were 9.0 (CI: 6.2 to 13.1) and 21.8 (CI: 5.1 to 93.5), respectively, and were 5.9 (CI: 4.4 - 7.8) and 9.7 (CI: 4.7 - 19.9) in the other.[PMID 21506741][PMID 21506748]
[PMID 23698811] MUC5B Promoter Variant Is Not Associated With Myositis-Related Interstitial Lung Disease
[PMID 23940607] The MUC5B Variant Is Associated with Idiopathic Pulmonary Fibrosis but Not with Systemic Sclerosis Interstitial Lung Disease in the European Caucasian Population
[PMID 24429156] Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study
[PMID 24434656] Association between MUC5 B and TERT polymorphisms and different interstitial lung disease phenotypes [PMID 23321605] Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis.
[PMID 23692170] MUC5B promoter polymorphism and interstitial lung abnormalities.
[PMID 23695349] Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis.
[PMID 25184687] The Role of Bacteria in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis
[PMID 25192356] Genome Sequencing of Idiopathic Pulmonary Fibrosis in Conjunction with a Medical School Human Anatomy Course
[PMID 25275363] The MUC5B promoter polymorphism is associated with IPF in a Mexican cohort but is rare among Asian ancestries
|Disease||Pulmonary fibrosis Idiopathic fibrosing alveolitis|
|CLNDBN||Pulmonary fibrosis, idiopathic, susceptibility to Idiopathic fibrosing alveolitis, chronic form|
|CLNSRC||OMIM Allelic Variant|
[PMID 25926289] A meta-analysis examining the association between the MUC5B rs35705950 T/G polymorphism and susceptibility to idiopathic pulmonary fibrosis
[PMID 26512610] Association Between the MUC5B Promoter Polymorphism rs35705950 and Idiopathic Pulmonary Fibrosis: A Meta-analysis and Trial Sequential Analysis in Caucasian and Asian Populations [PMID 26823827] Association between MUC5B polymorphism and susceptibility and severity of idiopathic pulmonary fibrosis.