Have questions? Visit https://www.reddit.com/r/SNPedia

rs35742686

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(-;-) CYP2D6*3 homozygote
(-;A) carrier of one CYP2D6*3 allele
(A;A) 0 normal
ReferenceGRCh38 38.1/142
Chromosome22
Position42524244
GeneCYP2D6
is asnp
is mentioned by
dbSNPrs35742686
ebirs35742686
HLIrs35742686
Exacrs35742686
Varsomers35742686
Maprs35742686
PheGenIrs35742686
hapmaprs35742686
1000 genomesrs35742686
hgdprs35742686
ensemblrs35742686
gopubmedrs35742686
geneviewrs35742686
scholarrs35742686
googlers35742686
pharmgkbrs35742686
gwascentralrs35742686
openSNPrs35742686
23andMers35742686
23andMe allrs35742686
SNP Nexus

SNPshotrs35742686
SNPdbers35742686
MSV3drs35742686
GWAS Ctlgrs35742686
GMAF0.009183
Max Magnitude0
rs35742686, which is also known as 2549delA, is a SNP in the CYP2D6 gene.

The rs35742686(-) allele defines the CYP2D6*3 variant, which is inactive. [PMID 23130019OA-icon.png] Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the chilean population: comparison with caucasian and asian populations.


[PMID 23133420OA-icon.png] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.

ClinVar
Risk rs35742686(;)
Alt rs35742686(;)
Reference rs35742686(A;A)
Significance Drug-response
Disease Debrisoquine
Variation info
Gene CYP2D6
CLNDBN Debrisoquine, poor metabolism of
Reversed 1
HGVS NC_000022.10:g.42524244delT
CLNSRC OMIM Allelic Variant
CLNACC RCV000018390.25,