|?|| (A;A) (A;G) (G;G) ||28|
|Desc||PHOSPHATIDYLINOSITOL 3-KINASE, CATALYTIC, BETA; PIK3CB|
[PMID 17971428] A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents.
[PMID 17977952] Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children.
[PMID 18398029] Genetic polymorphisms involved in insulin-like growth factor (IGF) pathway in relation to mammographic breast density and IGF levels.
[PMID 18772892] Can genes for mammographic density inform cancer aetiology?
[PMID 19097921] In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes.
[PMID 20107106] Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle.
[PMID 24114431] SNPs within the GH signaling pathway are associated with the early IGF-I response to GH replacement therapy in GHD adults