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rs3735273

From SNPedia

Orientationminus
Stabilizedminus
Make rs3735273(A;A)
Make rs3735273(A;G)
Make rs3735273(G;G)
ReferenceGRCh38 38.1/141
Chromosome7
Position50529166
GeneDDC
is asnp
is mentioned by
dbSNPrs3735273
ebirs3735273
HLIrs3735273
Exacrs3735273
Varsomers3735273
Maprs3735273
PheGenIrs3735273
hapmaprs3735273
1000 genomesrs3735273
hgdprs3735273
ensemblrs3735273
gopubmedrs3735273
geneviewrs3735273
scholarrs3735273
googlers3735273
pharmgkbrs3735273
gwascentralrs3735273
openSNPrs3735273
23andMers3735273
23andMe allrs3735273
SNP Nexus

SNPshotrs3735273
SNPdbers3735273
MSV3drs3735273
GWAS Ctlgrs3735273
GMAF0.2787
Max Magnitude
? (A;A) (A;G) (G;G) 28

per OMIM, Ma et al. (2005) [PMID 15879433] found two different DDC haplotypes associated with nicotine dependence in African Americans and European Americans (with measures of smoking quantity [SQ], heaviness of smoking index [HSI], and the Fagerstrom test for ND [FTND])

  • in African Americans, rs921451(T), rs3735273(G), rs1451371(T), rs2060762(G), all three measures sig. associated after correction for multiple testing
  • in European Americans, rs921451(T), rs3735273(G), rs1451371(T), rs3757472(G), which showed a sig. assoc. w/ the SQ and FTND score
OMIM188890
DescTOBACCO Addiction, SUSCEPTIBILITY TO
Variant
Relatedalso
OMIM107930
DescDOPA DECARBOXYLASE; DDC
Variant
Relatedalso



[PMID 17184203] DOPA decarboxylase gene is associated with nicotine dependence.


GET Evidence
rs3735273
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.284532
summary