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rs3735653

From SNPedia

Orientationminus
Stabilizedminus
Make rs3735653(A;A)
Make rs3735653(A;G)
Make rs3735653(G;G)
ReferenceGRCh38 38.1/141
Chromosome7
Position155458738
GeneEN2
is asnp
is mentioned by
dbSNPrs3735653
ebirs3735653
HLIrs3735653
Exacrs3735653
Varsomers3735653
Maprs3735653
PheGenIrs3735653
hapmaprs3735653
1000 genomesrs3735653
hgdprs3735653
ensemblrs3735653
gopubmedrs3735653
geneviewrs3735653
scholarrs3735653
googlers3735653
pharmgkbrs3735653
gwascentralrs3735653
openSNPrs3735653
23andMers3735653
23andMe allrs3735653
SNP Nexus

SNPshotrs3735653
SNPdbers3735653
MSV3drs3735653
GWAS Ctlgrs3735653
GMAF0.4646
Max Magnitude
? (A;A) (A;G) (G;G) 28

[PMID 19270442] Haplotype analysis of the engrailed-2 gene in young-onset Parkinson's disease


[PMID 15024396] Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder.

"Flanking exonic SNPs (rs3735653 ...) did not display association."


[PMID 16252243OA-icon.png] Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus. - no association found between rs3735653 and ASD

"We have previously tested four SNPs (rs3735653, rs1861972, rs1861973, and rs2361689) that span the majority of the EN2 gene for association with ASD in 167 AGRE families (AGRE I data set) (Gharani et al. 2004). The rs3735653 and rs2361689 SNPs are located in exon 1 and exon 2, respectively, whereas the rs1861972 and rs1861973 SNPs are both located in the single intron. Significant association was observed for the common alleles of rs1861972 and rs1861973, both individually and as a haplotype (Gharani et al. 2004). In contrast, the two exonic SNPs were not associated with ASD."


[PMID 20050924] Family-based studies indicate association of Engrailed 2 gene with autism in an Indian population.