|?|| (A;A) (A;G) (G;G) ||28|
is a SNP in the DISC1
gene, known as R264Q.
[PMID 16389590] Associated with schizophrenia
[PMID 17673452] 13 single-nucleotide polymorphisms (SNPs) in 723 members of 179 Finnish Bipolar disorder families.
- rs751229(T) and rs3738401(A) was over-transmitted to males with psychotic disorder.
- under-transmitted rs821616(T) and rs1411771(T)
- The risk haplotype for psychotic disorder also associated to perseverations (P = 0.035; for rs751229 alone P = 0.0012), and a protective haplotype G-T-G with rs1655285 in addition to auditory attention (P = 0.0059).
|Desc||DISRUPTED IN SCHIZOPHRENIA 1; DISC1|
] Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.
[PMID 17997036] Association study of polymorphisms between DISC1 and schizophrenia in a Korean population.
[PMID 19197363] A genome-wide investigation of SNPs and CNVs in schizophrenia.
[PMID 19255581] Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
[PMID 19300510] The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.
[PMID 19693267] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
[PMID 20531374] Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia.
[PMID 21483430] Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes.
[PMID 21878470] Effect of DISC1 on the P300 Waveform in Psychosis.
|| not reviewed
|| Insufficiently evaluated not reviewed