Have questions? Visit https://www.reddit.com/r/SNPedia

rs373863828

From SNPedia

Orientationplus
Geno Mag Summary
(A;G) 1.5 1.35x increased obesity risk, at least for Samoans
(G;G) 0 common/normal


Make rs373863828(A;A)
ReferenceGRCh38.p2 38.2/147
Chromosome5
Position173108771
GeneCREBRF
is asnp
is mentioned by
dbSNPrs373863828
ebirs373863828
HLIrs373863828
Exacrs373863828
Varsomers373863828
Maprs373863828
PheGenIrs373863828
hapmaprs373863828
1000 genomesrs373863828
hgdprs373863828
ensemblrs373863828
gopubmedrs373863828
geneviewrs373863828
scholarrs373863828
googlers373863828
pharmgkbrs373863828
gwascentralrs373863828
openSNPrs373863828
23andMers373863828
23andMe allrs373863828
SNP Nexus

SNPshotrs373863828
SNPdbers373863828
MSV3drs373863828
GWAS Ctlgrs373863828
Max Magnitude1.5
10.1038/ng.3620 A thrifty variant in CREBRF strongly influences body mass index in Samoans (rs12513649 and rs373863828). The key finding is that rs373863828(A) is associated with a 35 per cent higher chance of obesity (i.e. odds ratio of 1.35), and this rare variant is far more common among Samoans than Africans, Europeans or East Asians.


However, since the frequency of this variant in Samoans is unlikely to have changed dramatically over the last 200 years, whereas the obesity rare in this population has increased dramatically, the variant on it's own is considered insufficient to lead to obesity. Instead, the change in diet and in other environmental factors (less exercise, for example) is likely to act in synergy with this variant to lead to increased risk for obesity.