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rs3738919

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1 Normal risk of developing rheumatoid arthritis
(A;C) 2 1.94x risk of developing rheumatoid arthritis
(C;C) 2.5 1.94x risk of developing rheumatoid arthritis
ReferenceGRCh38 38.1/141
Chromosome2
Position186656533
GeneITGAV
is asnp
is mentioned by
dbSNPrs3738919
ebirs3738919
HLIrs3738919
Exacrs3738919
Varsomers3738919
Maprs3738919
PheGenIrs3738919
hapmaprs3738919
1000 genomesrs3738919
hgdprs3738919
ensemblrs3738919
gopubmedrs3738919
geneviewrs3738919
scholarrs3738919
googlers3738919
pharmgkbrs3738919
gwascentralrs3738919
openSNPrs3738919
23andMers3738919
23andMe allrs3738919
SNP Nexus

SNPshotrs3738919
SNPdbers3738919
MSV3drs3738919
GWAS Ctlgrs3738919
GMAF0.2107
Max Magnitude2.5
? (A;A) (A;C) (C;C) 28
rs3738919, a SNP located in the ITGAV gene, was identified in a European study to be associated with rheumatoid arthritis (RA). [PMID 17615072OA-icon.png]

The risk allele for rs3738919 is the more common allele, (C). For the three European Caucasian populations studied (372 RA patients + 330 controls), and combining the (C;C) and (A;C) genotypes in comparison to the (A;A) genotype, the odds ratio for RA = 1.94 (CI: 1.3–2.9, p = 0.002). There was no significant difference in RA risk between those carrying one or two (C) alleles. [PMID 17615072OA-icon.png]

An editorial about this finding has been published. [PMID 18001496OA-icon.png]


[PMID 19818132OA-icon.png] The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets