Have questions? Visit https://www.reddit.com/r/SNPedia

rs3745274

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 common in clinvar
(T;T) 2
Make rs3745274(G;T)
ReferenceGRCh38 38.1/141
Chromosome19
Position41006936
GeneCYP2B6
is asnp
is mentioned by
dbSNPrs3745274
ebirs3745274
HLIrs3745274
Exacrs3745274
Varsomers3745274
Maprs3745274
PheGenIrs3745274
hapmaprs3745274
1000 genomesrs3745274
hgdprs3745274
ensemblrs3745274
gopubmedrs3745274
geneviewrs3745274
scholarrs3745274
googlers3745274
pharmgkbrs3745274
gwascentralrs3745274
openSNPrs3745274
23andMers3745274
23andMe allrs3745274
SNP Nexus

SNPshotrs3745274
SNPdbers3745274
MSV3drs3745274
GWAS Ctlgrs3745274
GMAF0.2677
Max Magnitude2
? (G;G) (G;T) (T;T) 28




[PMID 21715435] Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens


[PMID 21790905OA-icon.png] CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction


[PMID 21886015] Cytochrome P450 CYP2B6 genotypes and haplotypes in a Colombian population: identification of novel variant CYP2B6 alleles

[PMID 18728241OA-icon.png] Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: pharmacogenetic effect of CYP2B6 variation.

[PMID 18784455OA-icon.png] The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis.

[PMID 19076156OA-icon.png] Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.

[PMID 19154420OA-icon.png] The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC.

[PMID 19239339OA-icon.png] Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans.

[PMID 19371316OA-icon.png] CYP2B6 (c.516G-->T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients.

[PMID 19659438OA-icon.png] CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti.

[PMID 20459744OA-icon.png] Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study.

[PMID 20723261OA-icon.png] Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.

[PMID 21694616] CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone S-enantiomer.

[PMID 21854194] Distribution of polymorphisms in cytochrome P450 2B6, histocompatibility complex P5, chemokine coreceptor 5, and interleukin 28B genes in inhabitants from the central area of Argentina.

[PMID 21860339] Integration of absorption, distribution, metabolism, and elimination genotyping data into a population pharmacokinetic analysis of nevirapine.


[PMID 23080225OA-icon.png] Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants


GET Evidence
CYP2B6-Q172H
aa_change Gln172His
aa_change_short Q172H
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.29169
summary



[PMID 23249875] Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study


[PMID 22951632OA-icon.png] Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine


[PMID 24080498] Pharmacogenetic associations with plasma efavirenz concentrations and clinical correlates in a retrospective cohort of Ghanaian HIV-infected patients


[PMID 24260284OA-icon.png] CYP2B6 Non-Coding Variation Associated with Smoking Cessation Is Also Associated with Differences in Allelic Expression, Splicing, and Nicotine Metabolism Independent of Common Amino-Acid Changes


[PMID 23133420OA-icon.png] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.


[PMID 23524664] Influence of the CYP2B6 polymorphism on the pharmacokinetics of mitotane.


[PMID 23996099] ABCB1 and ABCC1 variants associated with virological failure of first-line protease inhibitors antiretroviral regimens in Northeast Brazil patients


ClinVar
Risk rs3745274(A,T;A,T)
Alt rs3745274(A,T;A,T)
Reference rs3745274(G;G)
Significance Drug-response
Disease nevirapine response - Other efavirenz response - Dosage methadone response - Dosage efavirenz response - Toxicity/ADR Efavirenz response
Variation info
Gene CYP2B6
CLNDBN nevirapine response - Other efavirenz response - Dosage methadone response - Dosage efavirenz response - Toxicity/ADR Efavirenz response
Reversed 0
HGVS NC_000019.9:g.41512841G>A; NC_000019.9:g.41512841G>T
CLNSRC PharmGKB Clinical Annotation PharmGKB OMIM Allelic Variant
CLNACC RCV000211158.1, RCV000211215.1, RCV000211243.1, RCV000211341.1, RCV000022520.27,



[PMID 25428516] Effects of CYP2B6 genetic polymorphisms in patients receiving cyclophosphamide combination chemotherapy for breast cancer


[PMID 26141406] Impact of the Cytochrome P450 2B6 (CYP2B6) Gene Polymorphism c.516G>T (rs3745274) on Propofol Dose Variability