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rs3749977

From SNPedia

ability to smell cut grass
Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 1 common (highest ability to smell cut grass)
(C;T) 1 lower ability to smell cut grass
(T;T) 1 lowest ability to smell cut grass
ReferenceGRCh38 38.1/141
Chromosome6
Position29112567
GeneOR2J3
is asnp
is mentioned by
dbSNPrs3749977
ebirs3749977
HLIrs3749977
Exacrs3749977
Varsomers3749977
Maprs3749977
PheGenIrs3749977
hapmaprs3749977
1000 genomesrs3749977
hgdprs3749977
ensemblrs3749977
gopubmedrs3749977
geneviewrs3749977
scholarrs3749977
googlers3749977
pharmgkbrs3749977
gwascentralrs3749977
openSNPrs3749977
23andMers3749977
23andMe allrs3749977
SNP Nexus

SNPshotrs3749977
SNPdbers3749977
MSV3drs3749977
GWAS Ctlgrs3749977
GMAF0.3219
Max Magnitude1
? (C;C) (C;T) (T;T) 28
rs3749977, also known as Arg226Gln, is a SNP in the olfactory receptor OR2J3 gene. The rarer allele is apparently always found with the rarer allele of rs28757581, according to [PMID 22714804OA-icon.png].

A study of 52 unrelated volunteers who were not anosmic tested their ability to detect cis-3-hexen-1-ol (C3HEX), a compound given off by "wounded" plants, most typically, cut grass. The rarer alleles of rs3749977 and rs28757581 were associated with a lowered ability to detect this smell.[PMID 22714804OA-icon.png]


ClinVar
Risk rs3749977(T;T)
Alt rs3749977(T;T)
Reference rs3749977(C;C)
Significance Other
Disease C3HEX
Variation info
Gene OR2J3
CLNDBN C3HEX, ability to smell
Reversed 1
HGVS NC_000006.11:g.29080344G>A
CLNSRC OMIM Allelic Variant
CLNACC RCV000033139.3,