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rs3750817

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) normal
(C;T) 2 0.78x reduced risk for breast cancer
(T;T) 2.4 0.64x reduced risk for breast cancer, and higher likelihood of favorable postmenopausal hormone therapy
ReferenceGRCh38 38.1/142
Chromosome10
Position121573063
GeneFGFR2
is asnp
is mentioned by
dbSNPrs3750817
ebirs3750817
HLIrs3750817
Exacrs3750817
Varsomers3750817
Maprs3750817
PheGenIrs3750817
hapmaprs3750817
1000 genomesrs3750817
hgdprs3750817
ensemblrs3750817
gopubmedrs3750817
geneviewrs3750817
scholarrs3750817
googlers3750817
pharmgkbrs3750817
gwascentralrs3750817
openSNPrs3750817
23andMers3750817
23andMe allrs3750817
SNP Nexus

SNPshotrs3750817
SNPdbers3750817
MSV3drs3750817
GWAS Ctlgrs3750817
GMAF0.3379
Max Magnitude2.4
? (C;C) (C;T) (T;T) 28
rs3750817 is a SNP in the fibroblast growth factor receptor 2 FGFR2 gene.

A study of 2,166 invasive breast cancer cases concluded that carriers of a rs3750817(T) allele had lower risk for cancer, with an estimated per-minor-allele odds ratio of 0.78. Success with hormone therapy to treat postmenopausal symptoms also correlated with the number of rs3750817(T) alleles. [PMID 19861516OA-icon.png]


[PMID 20056625OA-icon.png] Variation in the FGFR2 gene and the effect of a low-fat dietary pattern on invasive breast cancer


[PMID 21702935OA-icon.png] Genetic variants in the MRPS30 region and postmenopausal breast cancer risk


[PMID 21791674OA-icon.png] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium


[PMID 21822685] Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality

[PMID 18285324OA-icon.png] Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk.

GWAS snp
PMID [PMID 22951594]
Trait Breast cancer
Title A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese.
Risk Allele T
P-val 8E-8
Odds Ratio 1.22 [NR]


[PMID 26070784OA-icon.png] Genetic risk variants associated with in situ breast cancer