|| 0.78x reduced risk for breast cancer
|| 0.64x reduced risk for breast cancer, and higher likelihood of favorable postmenopausal hormone therapy
|?|| (C;C) (C;T) (T;T) ||28|
is a SNP in the fibroblast growth factor receptor 2 FGFR2
A study of 2,166 invasive breast cancer cases concluded that carriers of a rs3750817(T) allele had lower risk for cancer, with an estimated per-minor-allele odds ratio of 0.78. Success with hormone therapy to treat postmenopausal symptoms also correlated with the number of rs3750817(T) alleles.
[PMID 20056625] Variation in the FGFR2 gene and the effect of a low-fat dietary pattern on invasive breast cancer
[PMID 21702935] Genetic variants in the MRPS30 region and postmenopausal breast cancer risk
[PMID 21791674] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
[PMID 21822685] Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality
[PMID 18285324] Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk.
|| [PMID 22951594]
|| Breast cancer
|| A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese.
| Risk Allele
| Odds Ratio
|| 1.22 [NR]
[PMID 26070784] Genetic risk variants associated with in situ breast cancer