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rs3754777

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 1.5 slightly higher blood pressure if Caucasian
(A;G) slightly higher blood pressure if Caucasian
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome2
Position168159404
GeneSTK39
is asnp
is mentioned by
dbSNPrs3754777
ebirs3754777
HLIrs3754777
Exacrs3754777
Varsomers3754777
Maprs3754777
PheGenIrs3754777
hapmaprs3754777
1000 genomesrs3754777
hgdprs3754777
ensemblrs3754777
gopubmedrs3754777
geneviewrs3754777
scholarrs3754777
googlers3754777
pharmgkbrs3754777
gwascentralrs3754777
openSNPrs3754777
23andMers3754777
23andMe allrs3754777
SNP Nexus

SNPshotrs3754777
SNPdbers3754777
MSV3drs3754777
GWAS Ctlgrs3754777
GMAF0.1942
Max Magnitude1.5
? (A;A) (A;G) (G;G) 28
rs3754777 is a SNP in the serine threonine kinase 39 STK39 gene.

A study of ~1,000 Amish originally identified rs3754777 and another SNP also in the STK39 gene, rs6749447, as being significantly associated with hypertension. This association was then found to also hold in patient data analyzed from the Framingham Heart Study and the Diabetes Genetics Initiative. On average, each minor allele, in this case rs3754777(A), is associated with 2.0 mmHg higher systolic blood pressure and a 1.0 mm Hg higher diastolic pressure.10.1073/pnas.0808358106[PMID 20003416OA-icon.png] STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression

[PMID 20889219] STK39 is an independent risk factor for male hypertension in Han Chinese


[PMID 19114657OA-icon.png] From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.


[PMID 21228780] Novel genetic variations associated with salt sensitivity in the Korean population.

High Blood Pressure (Hypertension)


[PMID 23408757OA-icon.png] Association between Serine/Threonine Kinase 39 Gene Polymorphism, Hypertension, and Other Cardiovascular Risk Factors in Koreans


[PMID 23591986] Influence of obesity on association between genetic variants identified by genome-wide association studies and hypertension risk in Chinese children.